{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang Y"],"funding":["Natural Science Foundation of Tibet Autonomous Region","Central leading local project","The central government guided the local project &quot;research and demonstration of high-efficiency double lamb vaccine and main supporting technologies&quot;","Natural Science Foundation of Tibet Autonomous Region &quot;Research on the preparation of double lambshin vaccine for sheep by heavy ion irradiation technology&quot;"],"pagination":["2888"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9104299"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(9)"],"pubmed_abstract":["Dairy mastitis is a disease of dairy cattle caused by a variety of pathogenic microorganisms which has biought huge economic losses aused huge economic losses to the world. In this paper, Harmine derivatives and tetrahydro-β-carboline derivatives synthesized by the splice method are shown to have a good inhibitory effect on the pathogenic bacteria of dairy mastitis. The results of a bacteriostatic test on pathogenic bacteria of dairy cow mastitis (<i>S. dysgalactiae</i>, <i>S. pyogenes</i>, <i>B. subtilis</i> and <i>P. vulgaris</i>) showed that compound <b>7l</b> had the best bacteriostatic effect on <i>Streptococcus dysgalactiae</i>, with a mic value of 43.7 μ g/mL. When the concentration of <b>7l</b> was 1 × MIC and 2 × MIC, it had a significant inhibitory effect on <i>Streptococcus dysgalactiae</i>, and there was almost no growth of <i>Streptococcus dysgalactiae</i> at 4 × MIC. The binding properties of target compound <b>7l</b> to <i>amine oxidase [flavin-containing] A</i> protein were simulated by the molecular docking technique. The ligand <b>7l</b> achieved strong binding with the receptor through three hydrogen bonds. The hydrogen bonds were amino acid residues thr-52, arg-51 and ser-24, which are the main force for the compound to bind to active sites."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Synthesis and Antibacterial Study of Novel Harmine Derivatives and Tetrahydro-β-Carboline Derivatives In Vitro."],"pmcid":["PMC9104299"],"funding_grant_id":["ZRKX2021000123","XZ202101YD0019C","XZ202101ZR0070G"],"pubmed_authors":["Tang L","He D","Liang Y","Song T","Zhou D","He B"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and Antibacterial Study of Novel Harmine Derivatives and Tetrahydro-β-Carboline Derivatives In Vitro.","description":"Dairy mastitis is a disease of dairy cattle caused by a variety of pathogenic microorganisms which has biought huge economic losses aused huge economic losses to the world. In this paper, Harmine derivatives and tetrahydro-β-carboline derivatives synthesized by the splice method are shown to have a good inhibitory effect on the pathogenic bacteria of dairy mastitis. The results of a bacteriostatic test on pathogenic bacteria of dairy cow mastitis (<i>S. dysgalactiae</i>, <i>S. pyogenes</i>, <i>B. subtilis</i> and <i>P. vulgaris</i>) showed that compound <b>7l</b> had the best bacteriostatic effect on <i>Streptococcus dysgalactiae</i>, with a mic value of 43.7 μ g/mL. When the concentration of <b>7l</b> was 1 × MIC and 2 × MIC, it had a significant inhibitory effect on <i>Streptococcus dysgalactiae</i>, and there was almost no growth of <i>Streptococcus dysgalactiae</i> at 4 × MIC. The binding properties of target compound <b>7l</b> to <i>amine oxidase [flavin-containing] A</i> protein were simulated by the molecular docking technique. The ligand <b>7l</b> achieved strong binding with the receptor through three hydrogen bonds. The hydrogen bonds were amino acid residues thr-52, arg-51 and ser-24, which are the main force for the compound to bind to active sites.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-04-08T10:00:38.361Z","creation":"2025-02-19T00:56:54.18Z"},"accession":"S-EPMC9104299","cross_references":{"pubmed":["35566239"],"doi":["10.3390/molecules27092888"]}}