biostudies-literatureUnknown27(9)Farag MAThe present study aimed to assess metabolites heterogeneity among four major <i>Cinnamomum</i> species, including true cinnamon (<i>Cinnamomum verum</i>) and less explored species (<i>C. cassia</i>, <i>C. iners</i>, and <i>C. tamala</i>). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocyanidin was identified for the first time in <i>C. tamala,</i> along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in <i>C. verum</i> versus procyandins, dihydro-coumaroylglycosides, and coumarin in <i>C. cassia</i>. A total of 51 primary metabolites were detected using GC-MS analysis encompassing different classes, <i>viz</i>. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in <i>C. tamala</i>, erythritol in <i>C. iners</i>, and glucose and fructose in <i>C. verum</i> from Malaysia were major metabolites contributing to the discrimination among species.Molecules (Basel, Switzerland)2935https://www.ebi.ac.uk/biostudies/studies/S-EPMC9104325biostudies-literatureComparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC-MS and GC-MS and Chemometric Tools.PMC9104325Afifi SMMediani ADoll SFarag MAKabbash EMEsatbeyoglu TfalseComparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC-MS and GC-MS and Chemometric Tools.The present study aimed to assess metabolites heterogeneity among four major <i>Cinnamomum</i> species, including true cinnamon (<i>Cinnamomum verum</i>) and less explored species (<i>C. cassia</i>, <i>C. iners</i>, and <i>C. tamala</i>). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocyanidin was identified for the first time in <i>C. tamala,</i> along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in <i>C. verum</i> versus procyandins, dihydro-coumaroylglycosides, and coumarin in <i>C. cassia</i>. A total of 51 primary metabolites were detected using GC-MS analysis encompassing different classes, <i>viz</i>. sugars, fatty acids, and sugar alcohols, with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in <i>C. tamala</i>, erythritol in <i>C. iners</i>, and glucose and fructose in <i>C. verum</i> from Malaysia were major metabolites contributing to the discrimination among species.2022-01-01T00:00:00Z2022 May2025-04-22T11:52:29.432Z2025-02-19T03:41:50.052ZS-EPMC91043253556628410.3390/molecules27092935