biostudies-literatureUnknown45(2)Diniz IGThis study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous areGenetics and molecular biologye20210153https://www.ebi.ac.uk/biostudies/studies/S-EPMC9104643biostudies-literatureCommon BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon.PMC9104643Sacuena ERPAraujo GSPereira APFigueiredo FAPLDiniz IGCardoso-Costa GLNoce RRDSilva ANLMDHumemeier TMachado JLPGuerreiro JFLemes RBfalseCommon BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon.This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are2022-01-01T00:00:00Z20222025-04-04T19:32:41.01Z2025-02-19T02:57:47.613ZS-EPMC91046433556016110.1590/1678-4685-GMB-2021-0153