{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang CF"],"funding":["Excellent Scientific and Technological Innovation Team of Colleges and Universities of Jiangsu Province","National Natural Science Foundation of China"],"pagination":["1882"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9105414"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood-brain barrier (BBB) damage, accompanied by the reduction of gut microbiome-derived short-chain fatty acids (SCFAs). Here, we found that chronic stress aggravated these pathological changes and promoted the development of depressive-like behaviors in FruD mice. In detail, the decreased number of newborn neurons, mature neurons and neural stem cells (NSCs) in the hippocampus of FruD mice was worsened by chronic stress. Furthermore, chronic stress exacerbated the damage of BBB integrity with the decreased"],"journal":["Nutrients"],"pubmed_title":["Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood-Brain Barrier Damage."],"pmcid":["PMC9105414"],"funding_grant_id":["SUJIAOKE〔2021〕No.1","31872901"],"pubmed_authors":["Wang CY","Tang CF","Li SJ","Wang HO","Li JM","Wang JH","Wang QN","Zhou F"],"additional_accession":[]},"is_claimable":false,"name":"Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood-Brain Barrier Damage.","description":"Excessive fructose intake is associated with the increased risk of mental illness, such as depression, but the underlying mechanisms are poorly understood. Our previous study found that high fructose diet (FruD)-fed mice exhibited neuroinflammation, hippocampal neurogenesis decline and blood-brain barrier (BBB) damage, accompanied by the reduction of gut microbiome-derived short-chain fatty acids (SCFAs). Here, we found that chronic stress aggravated these pathological changes and promoted the development of depressive-like behaviors in FruD mice. In detail, the decreased number of newborn neurons, mature neurons and neural stem cells (NSCs) in the hippocampus of FruD mice was worsened by chronic stress. Furthermore, chronic stress exacerbated the damage of BBB integrity with the decreased","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-05T15:05:52.04Z","creation":"2025-04-05T15:05:52.04Z"},"accession":"S-EPMC9105414","cross_references":{"pubmed":["35565849"],"doi":["10.3390/nu14091882"]}}