{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aravindraja C"],"funding":["NIDCR NIH HHS"],"pagination":["5107"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9105503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Periodontitis (PD) is a polymicrobial dysbiotic immuno-inflammatory disease. It is more prevalent in males and has poorly understood pathogenic molecular mechanisms. Our primary objective was to characterize alterations in sex-specific microRNA (miRNA, miR) after periodontal bacterial infection. Using partial human mouth microbes (PAHMM) (<i>Streptococcus gordonii</i>, <i>Fusobacterium nucleatum</i>, <i>Porphyromonas gingivalis</i>, <i>Treponema denticola,</i> and <i>Tannerella forsythia</i>) in an ecological time-sequential polybacterial periodontal infection (ETSPPI) mouse model, we evaluated differential mandibular miRNA profiles by using high-throughput Nanostring nCounter<sup>®</sup> miRNA expression panels. All PAHMM mice showed bacterial colonization (100%) in the gingival surface, "],"journal":["International journal of molecular sciences"],"pubmed_title":["Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression."],"pmcid":["PMC9105503"],"funding_grant_id":["R01 DE028536"],"pubmed_authors":["Chan EKL","Kesavalu L","Aravindraja C","Kashef MR","Ghanta RK","Vekariya KM","Karanth S"],"additional_accession":[]},"is_claimable":false,"name":"Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression.","description":"Periodontitis (PD) is a polymicrobial dysbiotic immuno-inflammatory disease. It is more prevalent in males and has poorly understood pathogenic molecular mechanisms. Our primary objective was to characterize alterations in sex-specific microRNA (miRNA, miR) after periodontal bacterial infection. Using partial human mouth microbes (PAHMM) (<i>Streptococcus gordonii</i>, <i>Fusobacterium nucleatum</i>, <i>Porphyromonas gingivalis</i>, <i>Treponema denticola,</i> and <i>Tannerella forsythia</i>) in an ecological time-sequential polybacterial periodontal infection (ETSPPI) mouse model, we evaluated differential mandibular miRNA profiles by using high-throughput Nanostring nCounter<sup>®</sup> miRNA expression panels. All PAHMM mice showed bacterial colonization (100%) in the gingival surface, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-03T22:33:32.074Z","creation":"2024-10-16T02:36:37.761Z"},"accession":"S-EPMC9105503","cross_references":{"pubmed":["35563501"],"doi":["10.3390/ijms23095107"]}}