{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Watanabe T"],"funding":["Iketani Science and Technology Foundation","Tanaka Kikinzoku Memorial Foundation","Ogasawara Toshiaki Memorial Foundation","Nakatani Foundation","Terumo (Japan)","Japan Society for the Promotion of Science"],"pagination":["1823"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9105568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["The topology effects of cyclization on thermal phase transition behaviors were investigated for a series of amphiphilic Pluronic copolymers of both hydrophilic-hydrophobic-hydrophilic and hydrophobic-hydrophilic-hydrophobic block sequences. The dye solubilization measurements revealed the lowered critical micelle temperatures (<i>T</i><sub>CMT</sub>) along with the decreased micellization enthalpy (Δ<i>H</i><sub>mic</sub>) and entropy (Δ<i>S</i><sub>mic</sub>) for the cyclized species. Furthermore, the transmittance and dynamic light scattering (DLS) measurements indicated a block sequence-dependent effect on the clouding phenomena, where a profound decrease in cloud point (<i>T</i><sub>c</sub>) was only found for the copolymers with a hydrophilic-hydrophobic-hydrophilic block sequence. Th"],"journal":["Polymers"],"pubmed_title":["Topology and Sequence-Dependent Micellization and Phase Separation of Pluronic L35, L64, 10R5, and 17R4: Effects of Cyclization and the Chain Ends."],"pmcid":["PMC9105568"],"funding_grant_id":["21H01991","no grant number"],"pubmed_authors":["Tajima K","Satoh T","Watanabe T","Ono T","Yamamoto T","Chimura S","Ida D","Wang Y","Sato SI","Isono T"],"additional_accession":[]},"is_claimable":false,"name":"Topology and Sequence-Dependent Micellization and Phase Separation of Pluronic L35, L64, 10R5, and 17R4: Effects of Cyclization and the Chain Ends.","description":"The topology effects of cyclization on thermal phase transition behaviors were investigated for a series of amphiphilic Pluronic copolymers of both hydrophilic-hydrophobic-hydrophilic and hydrophobic-hydrophilic-hydrophobic block sequences. The dye solubilization measurements revealed the lowered critical micelle temperatures (<i>T</i><sub>CMT</sub>) along with the decreased micellization enthalpy (Δ<i>H</i><sub>mic</sub>) and entropy (Δ<i>S</i><sub>mic</sub>) for the cyclized species. Furthermore, the transmittance and dynamic light scattering (DLS) measurements indicated a block sequence-dependent effect on the clouding phenomena, where a profound decrease in cloud point (<i>T</i><sub>c</sub>) was only found for the copolymers with a hydrophilic-hydrophobic-hydrophilic block sequence. Th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T11:51:44.729Z","creation":"2025-02-19T03:41:53.232Z"},"accession":"S-EPMC9105568","cross_references":{"pubmed":["35566993"],"doi":["10.3390/polym14091823"]}}