biostudies-literatureWatanabe TIketani Science and Technology FoundationTanaka Kikinzoku Memorial FoundationOgasawara Toshiaki Memorial FoundationNakatani FoundationTerumo (Japan)Japan Society for the Promotion of Science1823https://www.ebi.ac.uk/biostudies/studies/S-EPMC9105568biostudies-literatureUnknown14(9)The topology effects of cyclization on thermal phase transition behaviors were investigated for a series of amphiphilic Pluronic copolymers of both hydrophilic-hydrophobic-hydrophilic and hydrophobic-hydrophilic-hydrophobic block sequences. The dye solubilization measurements revealed the lowered critical micelle temperatures (<i>T</i>_CMT) along with the decreased micellization enthalpy (Δ<i>H</i>_mic) and entropy (Δ<i>S</i>_mic) for the cyclized species. Furthermore, the transmittance and dynamic light scattering (DLS) measurements indicated a block sequence-dependent effect on the clouding phenomena, where a profound decrease in cloud point (<i>T</i>_c) was only found for the copolymers with a hydrophilic-hydrophobic-hydrophilic block sequence. ThPolymersTopology and Sequence-Dependent Micellization and Phase Separation of Pluronic L35, L64, 10R5, and 17R4: Effects of Cyclization and the Chain Ends.PMC910556821H01991no grant numberTajima KSatoh TWatanabe TOno TYamamoto TChimura SIda DWang YSato SIIsono TfalseTopology and Sequence-Dependent Micellization and Phase Separation of Pluronic L35, L64, 10R5, and 17R4: Effects of Cyclization and the Chain Ends.The topology effects of cyclization on thermal phase transition behaviors were investigated for a series of amphiphilic Pluronic copolymers of both hydrophilic-hydrophobic-hydrophilic and hydrophobic-hydrophilic-hydrophobic block sequences. The dye solubilization measurements revealed the lowered critical micelle temperatures (<i>T</i>_CMT) along with the decreased micellization enthalpy (Δ<i>H</i>_mic) and entropy (Δ<i>S</i>_mic) for the cyclized species. Furthermore, the transmittance and dynamic light scattering (DLS) measurements indicated a block sequence-dependent effect on the clouding phenomena, where a profound decrease in cloud point (<i>T</i>_c) was only found for the copolymers with a hydrophilic-hydrophobic-hydrophilic block sequence. Th2022-01-01T00:00:00Z2022 Apr2025-04-22T11:51:44.729Z2025-02-19T03:41:53.232ZS-EPMC91055683556699310.3390/polym14091823