{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(23)"],"submitter":["Murata Y"],"pubmed_abstract":["Herein, we describe a simple and general multi-component synthesis of 5-arylselanyluracils by the regioselective C-H selenation of uracils. Reactions of uracils with arylboronic acid and Se powder in the presence of AgNO<sub>3</sub> (10 mol%) at 120 °C under aerobic conditions afforded various 5-arylselanyluracils. The source of the introduced selanyl group was prepared from a commercially available arylboronic acid and Se powder in the reaction system, thereby ensuring a simple and efficient protocol. This reaction represents the first example of the synthesis of a 5-arylselanyluracil in a multi-component system."],"journal":["RSC advances"],"pagination":["14502-14508"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9105704"],"repository":["biostudies-literature"],"pubmed_title":["Silver-catalyzed three-component reaction of uracils, arylboronic acids, and selenium: synthesis of 5-arylselanyluracils."],"pmcid":["PMC9105704"],"pubmed_authors":["Matsumura M","Murata Y","Yasuike S","Nezaki R","Tsuchida S","Kitamura Y"],"additional_accession":[]},"is_claimable":false,"name":"Silver-catalyzed three-component reaction of uracils, arylboronic acids, and selenium: synthesis of 5-arylselanyluracils.","description":"Herein, we describe a simple and general multi-component synthesis of 5-arylselanyluracils by the regioselective C-H selenation of uracils. Reactions of uracils with arylboronic acid and Se powder in the presence of AgNO<sub>3</sub> (10 mol%) at 120 °C under aerobic conditions afforded various 5-arylselanyluracils. The source of the introduced selanyl group was prepared from a commercially available arylboronic acid and Se powder in the reaction system, thereby ensuring a simple and efficient protocol. This reaction represents the first example of the synthesis of a 5-arylselanyluracil in a multi-component system.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-04T12:42:05.089Z","creation":"2025-04-04T12:42:05.089Z"},"accession":"S-EPMC9105704","cross_references":{"pubmed":["35702214"],"doi":["10.1039/d2ra01685k"]}}