{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Shanghai Municipal health commission","China Key Scientific Grant Program"],"pagination":["2994"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9106066"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(9)"],"pubmed_abstract":["The antibiotic resistance rates of <i>Klebsiella pneumoniae</i> have been steadily increasing in recent years. Nevertheless, the metabolic features of the drug-resistant <i>Klebsiella pneumoniae</i> and its associated benefits for bacterial pathogenicity are far from expounded. This study aims to unravel the unique physiological and metabolic properties specific to drug-resistant <i>K. pneumoniae</i>. Using scanning electron microscopy (SEM), we observed a thicker extracellular mucus layer around a drug-resistant <i>K. pneumonia</i> strain (Kp-R) than a drug-sensitive <i>K. pneumonia</i> strain (Kp-S). Kp-R also produced more capsular polysaccharide (CPS) and biofilm, and appeared to have a significant competitive advantage when co-cultured with Kp-S. Moreover, Kp-R was easier to adhere to"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Inosine and D-Mannose Secreted by Drug-Resistant <i>Klebsiella pneumoniae</i> Affect Viability of Lung Epithelial Cells."],"pmcid":["PMC9106066"],"funding_grant_id":["GWV-10.1-XK01, 201940300","No.2021YFC0122500"],"pubmed_authors":["Shen J","Gu S","Guan W","Shu F","Wang Q","Zhang Y","Xiao W","Xie L","Zhang L","Wang J","Tang Y","Zhou Z"],"additional_accession":[]},"is_claimable":false,"name":"Inosine and D-Mannose Secreted by Drug-Resistant <i>Klebsiella pneumoniae</i> Affect Viability of Lung Epithelial Cells.","description":"The antibiotic resistance rates of <i>Klebsiella pneumoniae</i> have been steadily increasing in recent years. Nevertheless, the metabolic features of the drug-resistant <i>Klebsiella pneumoniae</i> and its associated benefits for bacterial pathogenicity are far from expounded. This study aims to unravel the unique physiological and metabolic properties specific to drug-resistant <i>K. pneumoniae</i>. Using scanning electron microscopy (SEM), we observed a thicker extracellular mucus layer around a drug-resistant <i>K. pneumonia</i> strain (Kp-R) than a drug-sensitive <i>K. pneumonia</i> strain (Kp-S). Kp-R also produced more capsular polysaccharide (CPS) and biofilm, and appeared to have a significant competitive advantage when co-cultured with Kp-S. Moreover, Kp-R was easier to adhere to","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-22T11:53:36.319Z","creation":"2024-10-15T17:48:34.471Z"},"accession":"S-EPMC9106066","cross_references":{"pubmed":["35566345"],"doi":["10.3390/molecules27092994"]}}