biostudies-literatureZhang YShanghai Municipal health commissionChina Key Scientific Grant Program2994https://www.ebi.ac.uk/biostudies/studies/S-EPMC9106066biostudies-literatureUnknown27(9)The antibiotic resistance rates of <i>Klebsiella pneumoniae</i> have been steadily increasing in recent years. Nevertheless, the metabolic features of the drug-resistant <i>Klebsiella pneumoniae</i> and its associated benefits for bacterial pathogenicity are far from expounded. This study aims to unravel the unique physiological and metabolic properties specific to drug-resistant <i>K. pneumoniae</i>. Using scanning electron microscopy (SEM), we observed a thicker extracellular mucus layer around a drug-resistant <i>K. pneumonia</i> strain (Kp-R) than a drug-sensitive <i>K. pneumonia</i> strain (Kp-S). Kp-R also produced more capsular polysaccharide (CPS) and biofilm, and appeared to have a significant competitive advantage when co-cultured with Kp-S. Moreover, Kp-R was easier to adhere toMolecules (Basel, Switzerland)Inosine and D-Mannose Secreted by Drug-Resistant <i>Klebsiella pneumoniae</i> Affect Viability of Lung Epithelial Cells.PMC9106066GWV-10.1-XK01, 201940300No.2021YFC0122500Shen JGu SGuan WShu FWang QZhang YXiao WXie LZhang LWang JTang YZhou ZfalseInosine and D-Mannose Secreted by Drug-Resistant <i>Klebsiella pneumoniae</i> Affect Viability of Lung Epithelial Cells.The antibiotic resistance rates of <i>Klebsiella pneumoniae</i> have been steadily increasing in recent years. Nevertheless, the metabolic features of the drug-resistant <i>Klebsiella pneumoniae</i> and its associated benefits for bacterial pathogenicity are far from expounded. This study aims to unravel the unique physiological and metabolic properties specific to drug-resistant <i>K. pneumoniae</i>. Using scanning electron microscopy (SEM), we observed a thicker extracellular mucus layer around a drug-resistant <i>K. pneumonia</i> strain (Kp-R) than a drug-sensitive <i>K. pneumonia</i> strain (Kp-S). Kp-R also produced more capsular polysaccharide (CPS) and biofilm, and appeared to have a significant competitive advantage when co-cultured with Kp-S. Moreover, Kp-R was easier to adhere to2022-01-01T00:00:00Z2022 May2025-04-22T11:53:36.319Z2024-10-15T17:48:34.471ZS-EPMC91060663556634510.3390/molecules27092994