{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin C"],"funding":["National Key R&D Program of China","National Key R&D Program of China","CAMS Innovation Fund for Medical Sciences","National Natural Science Foundation of China"],"pagination":["1385-1395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9106624"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(6)"],"pubmed_abstract":["The present study was the first prospective cohort evaluated the efficacy and safety of different doses of calcitriol in XLH children. The results suggested that a dose of 40 ng/kg/day calcitriol, compared with 20 ng/kg/day, was more effective in relieving the rickets, with similar safety outcomes. Further investigations were expected to set more dose groups.Introduction
Dose recommended for calcitriol in X-linked hypophosphatemia (XLH) varies in different studies. Therefore, we aimed to compare the efficacy as well as the safety of 20 ng/kg/d and 40 ng/kg/d calcitriol in Chinese XLH pediatrics population.Methods
A 2-year, randomized, open-label, prospective study recruited 68 XLH children, which were randomized to receive either 40 ng/kg/day or 20 ng/kg/day calcitriol. Eff"],"journal":["Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"],"pubmed_title":["The efficacy and safety of different doses of calcitriol combined with neutral phosphate in X-linked hypophosphatemia: a prospective study."],"pmcid":["PMC9106624"],"funding_grant_id":["2016-I2M-3-003","2018YFA 0800801","81970757"],"pubmed_authors":["Xu L","Xing X","Wu B","Zhao Z","Li M","Meng X","Xia W","Jiang Y","Wang O","Jin C","Ni X","Zhang C","Chi Y","Jiajue R"],"additional_accession":[]},"is_claimable":false,"name":"The efficacy and safety of different doses of calcitriol combined with neutral phosphate in X-linked hypophosphatemia: a prospective study.","description":"The present study was the first prospective cohort evaluated the efficacy and safety of different doses of calcitriol in XLH children. The results suggested that a dose of 40 ng/kg/day calcitriol, compared with 20 ng/kg/day, was more effective in relieving the rickets, with similar safety outcomes. Further investigations were expected to set more dose groups.Introduction
Dose recommended for calcitriol in X-linked hypophosphatemia (XLH) varies in different studies. Therefore, we aimed to compare the efficacy as well as the safety of 20 ng/kg/d and 40 ng/kg/d calcitriol in Chinese XLH pediatrics population.Methods
A 2-year, randomized, open-label, prospective study recruited 68 XLH children, which were randomized to receive either 40 ng/kg/day or 20 ng/kg/day calcitriol. Eff","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T03:19:21.429Z","creation":"2024-11-05T22:58:20.716Z"},"accession":"S-EPMC9106624","cross_references":{"pubmed":["35088103"],"doi":["10.1007/s00198-021-06221-w"]}}