biostudies-literatureJin CNational Key R&amp;D Program of ChinaNational Key R&D Program of ChinaCAMS Innovation Fund for Medical SciencesNational Natural Science Foundation of China1385-1395https://www.ebi.ac.uk/biostudies/studies/S-EPMC9106624biostudies-literatureUnknown33(6)The present study was the first prospective cohort evaluated the efficacy and safety of different doses of calcitriol in XLH children. The results suggested that a dose of 40 ng/kg/day calcitriol, compared with 20 ng/kg/day, was more effective in relieving the rickets, with similar safety outcomes. Further investigations were expected to set more dose groups.<h4>Introduction</h4>Dose recommended for calcitriol in X-linked hypophosphatemia (XLH) varies in different studies. Therefore, we aimed to compare the efficacy as well as the safety of 20 ng/kg/d and 40 ng/kg/d calcitriol in Chinese XLH pediatrics population.<h4>Methods</h4>A 2-year, randomized, open-label, prospective study recruited 68 XLH children, which were randomized to receive either 40 ng/kg/day or 20 ng/kg/day calcitriol. EffOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USAThe efficacy and safety of different doses of calcitriol combined with neutral phosphate in X-linked hypophosphatemia: a prospective study.PMC91066242016-I2M-3-0032018YFA 080080181970757Xu LXing XWu BZhao ZLi MMeng XXia WJiang YWang OJin CNi XZhang CChi YJiajue RfalseThe efficacy and safety of different doses of calcitriol combined with neutral phosphate in X-linked hypophosphatemia: a prospective study.The present study was the first prospective cohort evaluated the efficacy and safety of different doses of calcitriol in XLH children. The results suggested that a dose of 40 ng/kg/day calcitriol, compared with 20 ng/kg/day, was more effective in relieving the rickets, with similar safety outcomes. Further investigations were expected to set more dose groups.<h4>Introduction</h4>Dose recommended for calcitriol in X-linked hypophosphatemia (XLH) varies in different studies. Therefore, we aimed to compare the efficacy as well as the safety of 20 ng/kg/d and 40 ng/kg/d calcitriol in Chinese XLH pediatrics population.<h4>Methods</h4>A 2-year, randomized, open-label, prospective study recruited 68 XLH children, which were randomized to receive either 40 ng/kg/day or 20 ng/kg/day calcitriol. Eff2022-01-01T00:00:00Z2022 Jun2025-04-04T03:19:21.429Z2024-11-05T22:58:20.716ZS-EPMC91066243508810310.1007/s00198-021-06221-w