biostudies-literaturePeckham MNCATS NIH HHS1211-1217https://www.ebi.ac.uk/biostudies/studies/S-EPMC9106860biostudies-literatureUnknown125(8)<h4>Objective</h4>To investigate a possible link between breast and thyroid cancer.<h4>Methods</h4>A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics.<h4>Results</h4>A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50-5.18).<h4>Conclusion</h4>There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.Journal of surgical oncologyBreast and thyroid cancer: A multicenter study with Accrual to Clinical Trials Network.PMC9106860UL1 TR001872U54 TR001629UL1 TR001860UL1 TR002014UL1 TR001998UL1 TR001414UL1 TR000005UL1 TR003107Syed SArmstrong WBPeckham MGal TJFarwell DGStack BCRussell MDGoldenberg DKing DSpencer HJSolis RNfalseBreast and thyroid cancer: A multicenter study with Accrual to Clinical Trials Network.<h4>Objective</h4>To investigate a possible link between breast and thyroid cancer.<h4>Methods</h4>A multicenter retrospective review of patients in the electronic medical records of six Accrual to Clinical Trial (ACT) institutions with both breast cancer and thyroid carcinoma. Each center queried its data using a predefined data dictionary. Information on thyroid and breast cancer included dates of diagnosis, histology, and patient demographics.<h4>Results</h4>A random-effects model was used. There were 4.24 million women's records screened, 44 605 with breast cancer and 11 846 with thyroid cancer. The relative risks observed at each institution ranged from 0.49 to 13.47. The combined risk ratio (RR) estimate was 1.77 (95% confidence interval: 0.50-5.18).<h4>Conclusion</h4>There was no association between the risk of developing thyroid cancer and being a breast cancer survivor compared to no history of breast cancer, but the range of relative risks among the participating institutions was wide. Our findings warrant further study of more institutions with larger sample size. Additionally, further analysis of the significance of regional RR differences may be enlightening.2022-01-01T00:00:00Z2022 Jun2025-04-26T22:55:17.704Z2025-04-06T17:25:19.409ZS-EPMC91068603519592310.1002/jso.26825