{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Escarcega RD"],"funding":["NIA NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)"],"pagination":["461"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9106988"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["Coronavirus disease (COVID-19), caused by SARS-CoV-2, leads to symptoms ranging from asymptomatic disease to death. Although males are more susceptible to severe symptoms and higher mortality due to COVID-19, patient sex has rarely been examined. Sex-associated metabolic changes may implicate novel biomarkers and therapeutic targets to treat COVID-19. Here, using serum samples, we performed global metabolomic analyses of uninfected and SARS-CoV-2-positive male and female patients with severe COVID-19. Key metabolic pathways that demonstrated robust sex differences in COVID-19 groups, but not in controls, involved lipid metabolism, pentose pathway, bile acid metabolism, and microbiome-related metabolism of aromatic amino acids, including tryptophan and tyrosine. Unsupervised statistical analysis showed a profound sexual dimorphism in correlations between patient-specific clinical parameters and their global metabolic profiles. Identification of sex-specific metabolic changes in severe COVID-19 patients is an important knowledge source for researchers striving for development of potential sex-associated biomarkers and druggable targets for COVID-19 patients."],"journal":["Cell death & disease"],"pubmed_title":["Sex differences in global metabolomic profiles of COVID-19 patients."],"pmcid":["PMC9106988"],"funding_grant_id":["R01 MH127856","1RF1AG068292","RF1 AG068292"],"pubmed_authors":["Tsvetkov AS","Escarcega RD","Torres G","Juneja S","Tabor N","Ganesh BP","McCullough LD","Honarpisheh P","Colpo GD","Couture L","Ortiz GJ","Ahnstedt HW","Sollome J","Liu F","Choi HA"],"additional_accession":[]},"is_claimable":false,"name":"Sex differences in global metabolomic profiles of COVID-19 patients.","description":"Coronavirus disease (COVID-19), caused by SARS-CoV-2, leads to symptoms ranging from asymptomatic disease to death. Although males are more susceptible to severe symptoms and higher mortality due to COVID-19, patient sex has rarely been examined. Sex-associated metabolic changes may implicate novel biomarkers and therapeutic targets to treat COVID-19. Here, using serum samples, we performed global metabolomic analyses of uninfected and SARS-CoV-2-positive male and female patients with severe COVID-19. Key metabolic pathways that demonstrated robust sex differences in COVID-19 groups, but not in controls, involved lipid metabolism, pentose pathway, bile acid metabolism, and microbiome-related metabolism of aromatic amino acids, including tryptophan and tyrosine. Unsupervised statistical analysis showed a profound sexual dimorphism in correlations between patient-specific clinical parameters and their global metabolic profiles. Identification of sex-specific metabolic changes in severe COVID-19 patients is an important knowledge source for researchers striving for development of potential sex-associated biomarkers and druggable targets for COVID-19 patients.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-29T22:25:13.063Z","creation":"2025-04-04T19:42:28.054Z"},"accession":"S-EPMC9106988","cross_references":{"pubmed":["35568706"],"doi":["10.1038/s41419-022-04861-2"]}}