{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu D"],"funding":["NINDS NIH HHS"],"pagination":["464-469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9109820"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["603(7901)"],"pubmed_abstract":["The brain generates complex sequences of movements that can be flexibly configured based on behavioural context or real-time sensory feedback<sup>1</sup>, but how this occurs is not fully understood. Here we developed a 'sequence licking' task in which mice directed their tongue to a target that moved through a series of locations. Mice could rapidly branch the sequence online based on tactile feedback. Closed-loop optogenetics and electrophysiology revealed that the tongue and jaw regions of the primary somatosensory (S1TJ) and motor (M1TJ) cortices<sup>2</sup> encoded and controlled tongue kinematics at the level of individual licks. By contrast, the tongue 'premotor' (anterolateral motor) cortex<sup>3-10</sup> encoded latent variables including intended lick angle, sequence identity and progress towards the reward that marked successful sequence execution. Movement-nonspecific sequence branching signals occurred in the anterolateral motor cortex and M1TJ. Our results reveal a set of key cortical areas for flexible and context-informed sequence generation."],"journal":["Nature"],"pubmed_title":["Cortical processing of flexible and context-dependent sensorimotor sequences."],"pmcid":["PMC9109820"],"funding_grant_id":["R01 NS104834","R01 NS089652","P30 NS050274"],"pubmed_authors":["Delgado AM","Xu D","Dong M","Chen Y","Zhang L","O'Connor DH","Hughes NC"],"additional_accession":[]},"is_claimable":false,"name":"Cortical processing of flexible and context-dependent sensorimotor sequences.","description":"The brain generates complex sequences of movements that can be flexibly configured based on behavioural context or real-time sensory feedback<sup>1</sup>, but how this occurs is not fully understood. Here we developed a 'sequence licking' task in which mice directed their tongue to a target that moved through a series of locations. Mice could rapidly branch the sequence online based on tactile feedback. Closed-loop optogenetics and electrophysiology revealed that the tongue and jaw regions of the primary somatosensory (S1TJ) and motor (M1TJ) cortices<sup>2</sup> encoded and controlled tongue kinematics at the level of individual licks. By contrast, the tongue 'premotor' (anterolateral motor) cortex<sup>3-10</sup> encoded latent variables including intended lick angle, sequence identity and progress towards the reward that marked successful sequence execution. Movement-nonspecific sequence branching signals occurred in the anterolateral motor cortex and M1TJ. Our results reveal a set of key cortical areas for flexible and context-informed sequence generation.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-05T16:10:10.47Z","creation":"2025-04-05T16:10:10.47Z"},"accession":"S-EPMC9109820","cross_references":{"pubmed":["35264793"],"doi":["10.1038/s41586-022-04478-7"]}}