biostudies-literatureUnknown15Jeiziner C<h4>Purpose</h4>Pharmacogenetic (PGx) panel testing could help to determine the heritable component of a rheumatoid arthritis (RA) patient's susceptibility for therapy failure and/or adverse drug reactions (ADRs) from methotrexate (MTX). Considering the literature mentioning the potential applicability of PGx panel testing within MTX regimens, we discuss the case of a patient who was treated with MTX, suffered from ADRs, and obtained a reactive PGx panel testing.<h4>Genotyping</h4>We used a commercial PGx panel test involving the ABC-transporters P-glycoprotein (P-gp; gene: <i>ABCB1</i>), and breast cancer resistance protein (BCRP; gene: <i>ABCG2</i>), the solute carriers reduced folate carrier 1 (RFC1; gene: <i>SLC19A1</i>), and organic anion transporting polypeptide 1B1 (OATP1B1; gene: <Pharmacogenomics and personalized medicine465-475https://www.ebi.ac.uk/biostudies/studies/S-EPMC9109898biostudies-literatureIs Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? - A Case Report.PMC9109898Meyer Zu Schwabedissen HEAllemann SSJeiziner CHersberger KEfalseIs Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? - A Case Report.<h4>Purpose</h4>Pharmacogenetic (PGx) panel testing could help to determine the heritable component of a rheumatoid arthritis (RA) patient's susceptibility for therapy failure and/or adverse drug reactions (ADRs) from methotrexate (MTX). Considering the literature mentioning the potential applicability of PGx panel testing within MTX regimens, we discuss the case of a patient who was treated with MTX, suffered from ADRs, and obtained a reactive PGx panel testing.<h4>Genotyping</h4>We used a commercial PGx panel test involving the ABC-transporters P-glycoprotein (P-gp; gene: <i>ABCB1</i>), and breast cancer resistance protein (BCRP; gene: <i>ABCG2</i>), the solute carriers reduced folate carrier 1 (RFC1; gene: <i>SLC19A1</i>), and organic anion transporting polypeptide 1B1 (OATP1B1; gene: <2022-01-01T00:00:00Z20222025-04-05T11:03:17.441Z2025-04-05T11:03:17.441ZS-EPMC91098983558647710.2147/PGPM.S354011