{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lewis NM"],"funding":["National Center for Advancing Translational Sciences","National Institute of Allergy and Infectious Diseases","NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","US Centers for Disease Control and Prevention","National Institutes of Health","NIGMS NIH HHS","NIH HHS"],"pagination":["1694-1700"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9113447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["225(10)"],"pubmed_abstract":["Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden."],"journal":["The Journal of infectious diseases"],"pubmed_title":["Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021."],"pmcid":["PMC9113447"],"funding_grant_id":["UL1 TR002243","K23 GM129661","1K23AI137321","K23 AI137321","75D30121F00002","T32 HL087738","T32 GM135169","K23 HL153584"],"pubmed_authors":["Douin D","Ghamande SA","Gordon AJ","Thornton-Thompson S","Ouellette S","Ghamande S","Murthy K","Baughman A","Chang SY","Zepeski A","Martin ET","Huynh D","Crider CD","Seiler S","Poynter B","Caspers S","Visweswaran A","Settele N","Naioti EA","Bowers R","Brown SM","Beeram M","Self WH","Womack KN","Calhoun N","Walter A","Kaniclides A","Kampe C","Halasa N","Anderson LA","McNeal TA","Garner O","Chandrasekaran S","Maldonado PN","Zouyed Z","Truscon R","Hough CL","Douin DJ","Lauring AS","Hager DN","Arroliga A","Sibenaller Z","Zhu Y","Chappell JD","Briceno G","Thomas J","Gibbs KW","Verani JR","Zayed M","Tenforde MW","Thomas L","Paulson TC","Hart KW","Gershengorn H","Shapiro NI","Clark Files D","Mallow C","Clinansmith B","Qadir N","Driver C","Patel MM","Scharber T","Grijalva CG","Hendrickson A","Peltan ID","Parks L","Ten Lohuis CC","Herrick J","Hicks M","Mitchell M","McSpadden EJ","De Souza L","Prekker ME","Burnham CA","McDonald D","Ginder A","Olson L","Nassar P","Mohr NM","Exline MC","Goff J","Rice TW","Silverman E","Hink T","So P","Lewis NM","Schrag SJ","Kobayashi M","Frankel T","Mills E","Wilson JG","McKillop A","Hubel K","Arter OG","Henning DJ","Armbruster B","Shehu A","Tyler P","Karow S","Landreth L","Steingrub JS","Krol O","Carricato M","Babcock HM","Mares J","Steinbock KA","Gilbert J","Erickson HL","McHenry R","Ginde AA","Brennan C","McNeal T","Rhoads JP","Bongu J","Casey JD","Levitt J","Park D","Busse LW","IVY Network Collaborators","Mehkri O","Chambers I","Kwon JH","Johnson J","Ashok K","Wallace M","Rothman RE","Chen JT","Lindsell CJ","Valesano AL","Rivas C","Nair R","Gaglani M","Kindle R","Jensen K","Priest E","Stubblefield WB","Fong R","King J","Perez C","Fitzsimmons WJ","Bielak R","Valvano WD","Cass C","Gong MN","Hoffman E","Blair M","LaRose M","Short L","Mohamed A","Keipp Talbot H","Khan A","Stanley N","Blair C","Smith M","Stout L","Khan M","Jorgensen J","Duggal A","Robart E","Ettlinger J","Roque J","Kozikowski LA","Aston V"],"additional_accession":[]},"is_claimable":false,"name":"Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021.","description":"Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-07T17:57:54.324Z","creation":"2025-04-05T08:47:35.767Z"},"accession":"S-EPMC9113447","cross_references":{"pubmed":["34932114"],"doi":["10.1093/infdis/jiab619"]}}