{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kozhemiako N"],"funding":["National Institute of Neurological Disorders and Stroke","Stanley Center for Psychiatric Research, Broad Institute","National Heart, Lung, and Blood Institute","NIMH NIH HHS","Wuxi Mental Health Center","NHLBI NIH HHS","Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee","NIMHD NIH HHS","National Institute of Mental Health","National Institute on Minority Health and Health Disparities","Brain & Behavior Research Foundation Young Investigator and the Zhengxu and Ying He Foundation awards"],"pagination":["e76211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9113745"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and their relationship to waking event-related potentials and symptom severity. In 72 schizophrenia (SCZ) patients and 58 controls, we confirmed a marked reduction in sleep spindle density in SCZ and extended these findings to show that fast and slow spindle properties were largely uncorrelated. We also describe a novel measure of slow oscillation and spindle interaction that was attenuated in SCZ. The main sleep findings were replicated in a demographically distinct sample, and a joint model, based on multiple N"],"journal":["eLife"],"pubmed_title":["Non-rapid eye movement sleep and wake neurophysiology in schizophrenia."],"pmcid":["PMC9113745"],"funding_grant_id":["K23 MH118565","R03 MH108908","R21 HL145492","R01MH118298","R01 MH118298","R01 MH115045","R01 HL146339","R21 MD012738","R01 MH115045-01","R01 MH092638","K23MH118565","R01HL146339","NS108874","UG3 MH125273","R01MH092638","HB2020077"],"pubmed_authors":["Gai G","Shen L","Zou K","Guo Z","Huang H","Pan JQ","Wang G","Wang J","Hal MH","Purcell SM","Qin S","Kozhemiako N","Manoach D","Wang LA","Murphy M","Wang Z","Stickgold R","Yu X","Mylonas D","Zhou L","Law R","Coleman J","Zhou Z","Li S","Tan S","Jiang C","Zhu W"],"additional_accession":[]},"is_claimable":false,"name":"Non-rapid eye movement sleep and wake neurophysiology in schizophrenia.","description":"Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and their relationship to waking event-related potentials and symptom severity. In 72 schizophrenia (SCZ) patients and 58 controls, we confirmed a marked reduction in sleep spindle density in SCZ and extended these findings to show that fast and slow spindle properties were largely uncorrelated. We also describe a novel measure of slow oscillation and spindle interaction that was attenuated in SCZ. The main sleep findings were replicated in a demographically distinct sample, and a joint model, based on multiple N","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-05T15:52:07.375Z","creation":"2025-04-05T15:52:07.375Z"},"accession":"S-EPMC9113745","cross_references":{"pubmed":["35578829"],"doi":["10.7554/eLife.76211"]}}