{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lecante LL"],"funding":["Agence Nationale de Sécurité du Médicament et des Produits de Santé","Agence nationale de la recherche"],"pagination":["1647-1661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9113793"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(6)"],"pubmed_abstract":["<h4>Context</h4>Acetaminophen (APAP, paracetamol) is widely used by pregnant women. Although long considered safe, growing evidence indicates that APAP is an endocrine disruptor since in utero exposure may be associated with a higher risk of male genital tract abnormalities. In rodents, fetal exposure has long-term effects on the reproductive function of female offspring. Human studies have also suggested harmful APAP exposure effects.<h4>Objective</h4>Given that disruption of fetal ovarian development may impact women's reproductive health, we investigated the effects of APAP on fetal human ovaries in culture.<h4>Design and setting</h4>Human ovarian fragments from 284 fetuses aged 7 to 12 developmental weeks (DW) were cultivated ex vivo for 7 days in the presence of human-relevant concent"],"journal":["The Journal of clinical endocrinology and metabolism"],"pubmed_title":["Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model."],"pmcid":["PMC9113793"],"funding_grant_id":["ANR-15-CE34-0001-01","2014S032"],"pubmed_authors":["Desdoits-Lethimonier C","Lavoue V","Gicquel T","Leverrier-Penna S","Mazaud-Guittot S","Lesne L","Costet N","Giton F","Lecante LL","Fromenty B","Rolland AD"],"additional_accession":[]},"is_claimable":false,"name":"Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.","description":"<h4>Context</h4>Acetaminophen (APAP, paracetamol) is widely used by pregnant women. Although long considered safe, growing evidence indicates that APAP is an endocrine disruptor since in utero exposure may be associated with a higher risk of male genital tract abnormalities. In rodents, fetal exposure has long-term effects on the reproductive function of female offspring. Human studies have also suggested harmful APAP exposure effects.<h4>Objective</h4>Given that disruption of fetal ovarian development may impact women's reproductive health, we investigated the effects of APAP on fetal human ovaries in culture.<h4>Design and setting</h4>Human ovarian fragments from 284 fetuses aged 7 to 12 developmental weeks (DW) were cultivated ex vivo for 7 days in the presence of human-relevant concent","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-18T12:04:17.806Z","creation":"2025-04-05T20:39:14.293Z"},"accession":"S-EPMC9113793","cross_references":{"pubmed":["35147701"],"doi":["10.1210/clinem/dgac080"]}}