biostudies-literatureLecante LLAgence Nationale de Sécurité du Médicament et des Produits de SantéAgence nationale de la recherche1647-1661https://www.ebi.ac.uk/biostudies/studies/S-EPMC9113793biostudies-literatureUnknown107(6)<h4>Context</h4>Acetaminophen (APAP, paracetamol) is widely used by pregnant women. Although long considered safe, growing evidence indicates that APAP is an endocrine disruptor since in utero exposure may be associated with a higher risk of male genital tract abnormalities. In rodents, fetal exposure has long-term effects on the reproductive function of female offspring. Human studies have also suggested harmful APAP exposure effects.<h4>Objective</h4>Given that disruption of fetal ovarian development may impact women's reproductive health, we investigated the effects of APAP on fetal human ovaries in culture.<h4>Design and setting</h4>Human ovarian fragments from 284 fetuses aged 7 to 12 developmental weeks (DW) were cultivated ex vivo for 7 days in the presence of human-relevant concentThe Journal of clinical endocrinology and metabolismAcetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.PMC9113793ANR-15-CE34-0001-012014S032Desdoits-Lethimonier CLavoue VGicquel TLeverrier-Penna SMazaud-Guittot SLesne LCostet NGiton FLecante LLFromenty BRolland ADfalseAcetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.<h4>Context</h4>Acetaminophen (APAP, paracetamol) is widely used by pregnant women. Although long considered safe, growing evidence indicates that APAP is an endocrine disruptor since in utero exposure may be associated with a higher risk of male genital tract abnormalities. In rodents, fetal exposure has long-term effects on the reproductive function of female offspring. Human studies have also suggested harmful APAP exposure effects.<h4>Objective</h4>Given that disruption of fetal ovarian development may impact women's reproductive health, we investigated the effects of APAP on fetal human ovaries in culture.<h4>Design and setting</h4>Human ovarian fragments from 284 fetuses aged 7 to 12 developmental weeks (DW) were cultivated ex vivo for 7 days in the presence of human-relevant concent2022-01-01T00:00:00Z2022 May2025-05-18T12:04:17.806Z2025-04-05T20:39:14.293ZS-EPMC91137933514770110.1210/clinem/dgac080