{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sanchez-Conde FG"],"funding":["American Heart Association","National Heart, Lung, and Blood Institute","NIGMS NIH HHS"],"pagination":["890368"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9113952"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["The ERG1 potassium channel, encoded by <i>KCNH2</i>, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered."],"journal":["Frontiers in molecular neuroscience"],"pubmed_title":["The ERG1 K<sup>+</sup> Channel and Its Role in Neuronal Health and Disease."],"pmcid":["PMC9113952"],"funding_grant_id":["T32 GM140223"],"pubmed_authors":["Jones DK","Jimenez-Vazquez EN","Auerbach DS","Sanchez-Conde FG"],"additional_accession":[]},"is_claimable":false,"name":"The ERG1 K<sup>+</sup> Channel and Its Role in Neuronal Health and Disease.","description":"The ERG1 potassium channel, encoded by <i>KCNH2</i>, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-20T03:05:03.979Z","creation":"2024-12-04T00:35:22.183Z"},"accession":"S-EPMC9113952","cross_references":{"pubmed":["35600076"],"doi":["10.3389/fnmol.2022.890368"]}}