biostudies-literatureSanchez-Conde FGAmerican Heart AssociationNational Heart, Lung, and Blood InstituteNIGMS NIH HHS890368https://www.ebi.ac.uk/biostudies/studies/S-EPMC9113952biostudies-literatureUnknown15The ERG1 potassium channel, encoded by <i>KCNH2</i>, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered.Frontiers in molecular neuroscienceThe ERG1 K⁺ Channel and Its Role in Neuronal Health and Disease.PMC9113952T32 GM140223Jones DKJimenez-Vazquez ENAuerbach DSSanchez-Conde FGfalseThe ERG1 K⁺ Channel and Its Role in Neuronal Health and Disease.The ERG1 potassium channel, encoded by <i>KCNH2</i>, has long been associated with cardiac electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology throughout the human body, including the brain. ERG1 is a regulator of neuronal excitability, ERG1 variants are associated with neuronal diseases (e.g., epilepsy and schizophrenia), and ERG1 serves as a potential therapeutic target for neuronal pathophysiology. This review summarizes the current state-of-the-field regarding the ERG1 channel structure and function, ERG1's relationship to the mammalian brain and highlights key questions that have yet to be answered.2022-01-01T00:00:00Z20222025-04-20T03:05:03.979Z2024-12-04T00:35:22.183ZS-EPMC91139523560007610.3389/fnmol.2022.890368