biostudies-literatureUnknown12(1)Goncalves LCOConselho Nacional de Desenvolvimento Científico e TecnológicoBrazilian Olympic CommitteCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFinanciadora de Estudos e ProjetosMerck-Sigma-AldrichWaters CorporationUniversidade Federal do Estado do Rio de JaneiroFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de JaneiroWe have been using sportomics to understand hypermetabolic stress. Cross Combat (CCombat) has recently been initiated as a high-intensity functional training method inspired by CrossFit. We used a CCombat session to induce metabolic stress and evaluated its effects on hydration and kidney function. Blood samples were collected from 16 elite-level professional male athletes engaged in training sessions over a 96-h protocol. Blood myoglobin increased by ~ 3.5-fold (119 ± 21 to 369 ± 62 nmol/L; p = .001) in response to the protocol, returning to the pre-exercise level within 48 h. Furthermore, D-dimer levels increased from 6.5 ± 0.6 to 79.4 ± 21.3 μmol/L (p < .001) in response to exercise decreasing during recovery with high variability among the studied athletes. Albuminemia and creatininemiScientific reports8150https://www.ebi.ac.uk/biostudies/studies/S-EPMC9114005biostudies-literatureSportomics suggests that albuminuria is a sensitive biomarker of hydration in cross combat.PMC9114005Verli MVAJurisica IGoncalves LCOPrado ESMagalhaes-Neto AMMuniz-Santos RJurisica LBassini ALopes JSSAndrade CMBCameron LCfalseSportomics suggests that albuminuria is a sensitive biomarker of hydration in cross combat.We have been using sportomics to understand hypermetabolic stress. Cross Combat (CCombat) has recently been initiated as a high-intensity functional training method inspired by CrossFit. We used a CCombat session to induce metabolic stress and evaluated its effects on hydration and kidney function. Blood samples were collected from 16 elite-level professional male athletes engaged in training sessions over a 96-h protocol. Blood myoglobin increased by ~ 3.5-fold (119 ± 21 to 369 ± 62 nmol/L; p = .001) in response to the protocol, returning to the pre-exercise level within 48 h. Furthermore, D-dimer levels increased from 6.5 ± 0.6 to 79.4 ± 21.3 μmol/L (p < .001) in response to exercise decreasing during recovery with high variability among the studied athletes. Albuminemia and creatininemi2022-01-01T00:00:00Z2022 May2025-05-29T20:30:28.538Z2025-05-29T20:30:28.538ZS-EPMC91140053558124210.1038/s41598-022-12079-7