biostudies-literatureUnknown13Terren IHezkuntza, Hizkuntza Politika Eta Kultura Saila, Eusko JaurlaritzaIkerbasque, Basque Foundation for ScienceOsasun Saila, Eusko JaurlaritzakoFundación Científica Asociación Española Contra el CáncerNatural killer (NK) cells are lymphocytes with a key role in the defense against viral infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs), under certain circumstances they exhibit adaptive and memory-like features. The latter may be achieved, among others, by a brief stimulation with interleukin (IL)-12, IL-15 and IL-18. These cytokine-induced memory-like (CIML) NK cells resemble the trained immunity observed in myeloid cells. CIML NK cells undergo transcriptional, epigenetic and metabolic reprogramming that, along with changes in the expression of cell surface receptors and components of cytotoxic granules, are responsible for their enhanced effector functions after a resting period. In addition, these memory-like NK cells persist for a long time,Frontiers in immunology884648https://www.ebi.ac.uk/biostudies/studies/S-EPMC9114299biostudies-literatureCytokine-Induced Memory-Like NK Cells: From the Basics to Clinical Applications.PMC9114299Borrego FZenarruzabeitia OTerren IAmarilla-Irusta AAstarloa-Pando GOrrantia AfalseCytokine-Induced Memory-Like NK Cells: From the Basics to Clinical Applications.Natural killer (NK) cells are lymphocytes with a key role in the defense against viral infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs), under certain circumstances they exhibit adaptive and memory-like features. The latter may be achieved, among others, by a brief stimulation with interleukin (IL)-12, IL-15 and IL-18. These cytokine-induced memory-like (CIML) NK cells resemble the trained immunity observed in myeloid cells. CIML NK cells undergo transcriptional, epigenetic and metabolic reprogramming that, along with changes in the expression of cell surface receptors and components of cytotoxic granules, are responsible for their enhanced effector functions after a resting period. In addition, these memory-like NK cells persist for a long time,2022-01-01T00:00:00Z20222025-04-19T12:09:08.33Z2025-04-19T12:09:08.33ZS-EPMC91142993560320810.3389/fimmu.2022.884648