{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["95(5)"],"submitter":["Arruda LCM"],"pubmed_abstract":["Rheumatoid arthritis (RA) patients present higher risk of SARS-CoV-2 infection (COVID-19), and proper management of the disease in this population requires a better understanding of how the immune system controls the virus. We analyzed the T cell and B cell phenotypes, and their repertoire in a pair of monozygotic twins with RA mismatched for COVID-19 infection. Twin- was not infected, while Twin+ was infected and effectively controlled the infection. We found no significant changes on the αβ T cell composition, while γδ T cells and B cells presented considerable expansion of memory population in Twin+ and robust T/B cell responses to several SARS-CoV-2 peptides. T cell receptor β/γ-chain and immunoglobulin heavy chain next-generation sequencing depicted a remarkable higher diversity in Tw"],"journal":["Scandinavian journal of immunology"],"pagination":["e13151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9115348"],"repository":["biostudies-literature"],"pubmed_title":["SARS-CoV-2 (COVID-19)-specific T cell and B cell responses in convalescent rheumatoid arthritis: Monozygotic twins pair case observation."],"pmcid":["PMC9115348"],"pubmed_authors":["Gaballa A","Makower B","Uhlin M","Da Silva Rodrigues R","Arruda LCM"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 (COVID-19)-specific T cell and B cell responses in convalescent rheumatoid arthritis: Monozygotic twins pair case observation.","description":"Rheumatoid arthritis (RA) patients present higher risk of SARS-CoV-2 infection (COVID-19), and proper management of the disease in this population requires a better understanding of how the immune system controls the virus. We analyzed the T cell and B cell phenotypes, and their repertoire in a pair of monozygotic twins with RA mismatched for COVID-19 infection. Twin- was not infected, while Twin+ was infected and effectively controlled the infection. We found no significant changes on the αβ T cell composition, while γδ T cells and B cells presented considerable expansion of memory population in Twin+ and robust T/B cell responses to several SARS-CoV-2 peptides. T cell receptor β/γ-chain and immunoglobulin heavy chain next-generation sequencing depicted a remarkable higher diversity in Tw","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-04T18:36:47.871Z","creation":"2024-11-14T23:45:15.395Z"},"accession":"S-EPMC9115348","cross_references":{"pubmed":["35212005"],"doi":["10.1111/sji.13151"]}}