biostudies-literatureUnknown327(19)UK TAVI Trial Investigators<h4>Importance</h4>Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical aortic valve replacement and is the treatment of choice for patients at high operative risk. The role of TAVI in patients at lower risk is unclear.<h4>Objective</h4>To determine whether TAVI is noninferior to surgery in patients at moderately increased operative risk.<h4>Design, setting, and participants</h4>In this randomized clinical trial conducted at 34 UK centers, 913 patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk due to age or comorbidity were enrolled between April 2014 and April 2018 and followed up through April 2019.<h4>Interventions</h4>TAVI using any valve with a CE mark (indicating conformity of the valveJAMA1875-1887https://www.ebi.ac.uk/biostudies/studies/S-EPMC9115619biostudies-literatureEffect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial.PMC9115619Metherell SYoung AWilliams LWain JNaylor HRadmore JRedwood SRHanzel LTaylor BDorman SHRanasinghe AUK TAVI Trial InvestigatorsCotton JCunningham NLynch JSionas MMcEntegart MBRajathurai THall IBirdi IAbrams KRCrowe JNewton JNadir ASarma JLuckraz HPanoulas VGibson CChin DHounsley KCalver AVillarreal EO'Sullivan MCockburn JMcLeod KLevy RKemp IRawlins JWilliams PAndrew GZamvar VKabir TGomes AMassey IKhogali SSHildick-Smith DHasan RO'Toole LAwad WIde Belder AMascaro JFarooq VWong LMarsh AMYadav RVahabi SMonaghan MJMahoney LDickerson DRidley PDDuncan AHickey MCunnington MSzafranek AOhri SKBaumbach AMalkin CJReed HKozlowski VGardener LMoat NEDoshi SNAltman DCrossman DCDalby MWebb ARahman Haley SBaig KKrasopoulos GWallis ADensem CGSuresh VMehta DDavies SWSzabolcs MSpyt TKhurana ADaniel TThompson EDeglurkar IRana BGoodwin ASaunders DYoung CPWinder WParker JPirone FJavangula KKnighton ABahlay BRonayne CMcDowell LClarkson NEvans BWoan WMack SSharma RWilkinson ISherwood MCleland JGFEngonidou LWilkinson LOommen AHyndman SAppasamy SZaman AFlapan AToff WDAyman GTownsend MMcQuade LBriffa NChelliah RJones SBounford KGriffiths RBarton JChiocchia VAtkinson BForrest MBowen SOldroyd KGAnderson RMariscalco GPickett EBoon NSchlosshan DOcampo MMatuszewski MChaudhry MMikhail GSomers KTapp LMacNab AJackson MClifton LYouhana ARombach ICox IDHewitt AWilmshurst NBarman CMalik IFairbairn TEdwards RJKhoo JStout MBell MAnderson JMuir DFYeh JKaul PAbu-Omar YBell SSkipper NGriffiths JGregory NDean JTsui SAndiapen MRamesh BCCooper GMuthuswamy AFonseca TChetty GWilson KSpeke LRay SSookhoo VProctor KSteeds RTsang GBose AMcAdam JSudarshan CGray AMRajakaruna CPalovaara Tde Belder MAButler MKharbanda RBaghai MSpence MSFraser DGWBanks KGough SGrech ETobin ADyer HFrame AChase ADavies WEdwards JMacCarthy PBland MChandrasekaran VMatthews EAlam MTownend JNRandall MByrne JLloyd SDavies LChowdhary SCruden NJohnston NWarsama SPearce KPintacasi JFancourt GHiles SSevillano AFatoba SLloyd CAggarwal RWhittaker ATang AGallego LUren NGThomson CCampton MThomas GHenderson RPessotto RFeeney SCharles TNicholas ZCobbe SMDutton SAndrews MNavaneethakrishnan AShaw RCrean PConroy SPMcClean RWheeler RThomas PJahangiri MMcMurray JCurzen NBigg JGardner DLoubani MNeville MNihoyannopoulos PAllen CKadir IBatra PMcPherson GRoberts EBowles RRoberts DMansouri ADeshpande RRoberts NBuch MSayeed RRoberts JOwens CGHamshere SFord IMullen MJKober LNaik SBarker DKumar PGroves PHFlather MDAl-Attar NMackie SBlackman DHodges EBarber VWang SShirkey BModi AMiddleton SAkhtar MOssei-Gerning NBarker TSingh SJeganathan RLudman PFRakhit DWendler OQuarto CRaja SGLockie SFagan CAdrego RKuyt KTrivedi UKovac JDalrymple-Hay MForlani SBanning APPrendergast CPrendergast BCurrie JHarrison UGrant SDas RBhattacharyya SKennon SEncarnacion DTreasure TNilsson AZacharkiw LRogers PRubie SHolder JVarcoe ROwens WAAlexander DGunning MGMills JDHarrison JKing RDobson LRobinson HSmith DRif BChukwuemeka ASmith BWaterworth PSmallwood ABawamia BKuduvalli MVasudevan VThambyrajah JLogtens EShah BDobbs KPalmer JRusk RBrecker SBrown SAl-Hussaini AfalseEffect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial.<h4>Importance</h4>Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical aortic valve replacement and is the treatment of choice for patients at high operative risk. The role of TAVI in patients at lower risk is unclear.<h4>Objective</h4>To determine whether TAVI is noninferior to surgery in patients at moderately increased operative risk.<h4>Design, setting, and participants</h4>In this randomized clinical trial conducted at 34 UK centers, 913 patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk due to age or comorbidity were enrolled between April 2014 and April 2018 and followed up through April 2019.<h4>Interventions</h4>TAVI using any valve with a CE mark (indicating conformity of the valve2022-01-01T00:00:00Z2022 May2025-04-06T00:21:50.621Z2025-04-06T00:21:50.621ZS-EPMC91156193557964110.1001/jama.2022.5776