biostudies-literatureJohnson WTNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNIDCR NIH HHSNational Institute of Dental and Craniofacial ResearchNational Institute of General Medical SciencesArthritis National Research Foundatione10288https://www.ebi.ac.uk/biostudies/studies/S-EPMC9115682biostudies-literatureUnknown7(2)Lipids constitute a diverse class of molecular regulators with ubiquitous physiological roles in sustaining life. These carbon-rich compounds are primarily sourced from exogenous sources and may be used directly as structural cellular building blocks or as a substrate for generating signaling mediators to regulate cell behavior. In both of these roles, lipids play a key role in both immune activation and suppression, leading to inflammation and resolution, respectively. The simple yet elegant structural properties of lipids encompassing size, hydrophobicity, and molecular weight enable unique biodistribution profiles that facilitate preferential accumulation in target tissues to modulate relevant immune cell subsets. Thus, the structural and functional properties of lipids can be leveragedBioengineering & translational medicineLipid-based regulators of immunity.PMC9115682846186R03 DE031009P30 AR073761T32 AR064194R25 GM083275Bottini NShah NJDorn NCOgbonna DAJohnson WTfalseLipid-based regulators of immunity.Lipids constitute a diverse class of molecular regulators with ubiquitous physiological roles in sustaining life. These carbon-rich compounds are primarily sourced from exogenous sources and may be used directly as structural cellular building blocks or as a substrate for generating signaling mediators to regulate cell behavior. In both of these roles, lipids play a key role in both immune activation and suppression, leading to inflammation and resolution, respectively. The simple yet elegant structural properties of lipids encompassing size, hydrophobicity, and molecular weight enable unique biodistribution profiles that facilitate preferential accumulation in target tissues to modulate relevant immune cell subsets. Thus, the structural and functional properties of lipids can be leveraged2022-01-01T00:00:00Z2022 May2025-04-25T18:04:21.951Z2024-11-19T16:31:21.466ZS-EPMC91156823560063710.1002/btm2.10288