{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Van Hao N"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["e862-e872"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9115864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Background
Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. Tetanus toxin acts within the CNS, where there is limited penetration of peripherally administered antitoxin; thus, intrathecal antitoxin administration might improve clinical outcomes compared with intramuscular injection.Methods
In a 2 × 2 factorial trial, all patients aged 16 years or older with a clinical diagnosis of generalised tetanus admitted to the intensive care unit of the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, were eligible for study entry. Participants were randomly assigned first to 3000 IU human or 21 000 U equine intramuscular antitoxin, then to either 500 IU intrathecal human antitoxin or sham procedure"],"journal":["The Lancet. Global health"],"pubmed_title":["Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial."],"pmcid":["PMC9115864"],"funding_grant_id":["204904/Z/16/Z","107367/Z/15/Z","MR/R015600/1"],"pubmed_authors":["Thwaites GE","Oanh PKN","van Doorn HR","Thuy DB","Turner HC","Loan HT","Thwaites CL","Thuy TTD","Phong NT","Wyncoll D","Van Vinh Chau N","Tan Thanh T","Geskus RB","Hong DD","Nguyen NT","Tho PV","Duong HTH","Hanh BTB","Nhat PTH","Dung NTP","Phu NH","Khanh PNQ","Nghia HDT","Day NP","Tuyen PT","Van Tan L","Van Hao N","Lieu PT","Kestelyn E","Yen LM"],"additional_accession":[]},"is_claimable":false,"name":"Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial.","description":"Background
Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. Tetanus toxin acts within the CNS, where there is limited penetration of peripherally administered antitoxin; thus, intrathecal antitoxin administration might improve clinical outcomes compared with intramuscular injection.Methods
In a 2 × 2 factorial trial, all patients aged 16 years or older with a clinical diagnosis of generalised tetanus admitted to the intensive care unit of the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, were eligible for study entry. Participants were randomly assigned first to 3000 IU human or 21 000 U equine intramuscular antitoxin, then to either 500 IU intrathecal human antitoxin or sham procedure","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-05-10T01:40:16.231Z","creation":"2025-02-19T02:57:21.806Z"},"accession":"S-EPMC9115864","cross_references":{"pubmed":["35561721"],"doi":["10.1016/S2214-109X(22)00117-6"]}}