{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo J"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["2752"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9117260"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Direct deoxyazidation of alcohols with NaN<sub>3</sub> is a straightforward method for the synthesis of widely used alkyl azides in organic chemistry. However, known methods have some limitations such as high reaction temperatures and narrow substrate scope. Herein, a general and practical method for the preparation of alkyl azides from alcohols using NaN<sub>3</sub> has been developed. N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) plays an important role in this deoxyazidation process, which converts a broad range of alcohols into alkyl azides at room temperature. The power of this deoxyazidation protocol has been demonstrated by successful late-stage deoxyazidation of natural products and pharmaceutically relevant molecules."],"journal":["Nature communications"],"pubmed_title":["SulfoxFluor-enabled deoxyazidation of alcohols with NaN<sub>3</sub>."],"pmcid":["PMC9117260"],"funding_grant_id":["21632009"],"pubmed_authors":["Guo J","Hu J","Wang X","Ni C","Wan X"],"additional_accession":[]},"is_claimable":false,"name":"SulfoxFluor-enabled deoxyazidation of alcohols with NaN<sub>3</sub>.","description":"Direct deoxyazidation of alcohols with NaN<sub>3</sub> is a straightforward method for the synthesis of widely used alkyl azides in organic chemistry. However, known methods have some limitations such as high reaction temperatures and narrow substrate scope. Herein, a general and practical method for the preparation of alkyl azides from alcohols using NaN<sub>3</sub> has been developed. N-tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) plays an important role in this deoxyazidation process, which converts a broad range of alcohols into alkyl azides at room temperature. The power of this deoxyazidation protocol has been demonstrated by successful late-stage deoxyazidation of natural products and pharmaceutically relevant molecules.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-18T22:59:51.729Z","creation":"2024-11-15T20:40:00.431Z"},"accession":"S-EPMC9117260","cross_references":{"pubmed":["35585073"],"doi":["10.1038/s41467-022-30132-x"]}}