biostudies-literatureOsterlund Oltmanns JRNational Institute on Alcohol Abuse and AlcoholismNIAAA NIH HHS861-875https://www.ebi.ac.uk/biostudies/studies/S-EPMC9117438biostudies-literatureUnknown46(5)<h4>Background</h4>Prenatal alcohol exposure (PAE) can produce deficits in a wide range of cognitive functions but is especially detrimental to behaviors requiring accurate spatial information processing. In open field environments, spatial behavior is organized such that animals establish "home bases" marked by long stops focused around one location. Progressions away from the home base are circuitous and slow, while progressions directed toward the home base are non-circuitous and fast. The impact of PAE on the organization of open field behavior has not been experimentally investigated.<h4>Methods</h4>In the present study, adult female and male rats with moderate PAE or saccharin exposure locomoted a circular high walled open field for 30 minutes under lighted conditions.<h4>Results</h4Alcoholism, clinical and experimental researchSexually dimorphic organization of open field behavior following moderate prenatal alcohol exposure.PMC9117438T32 AA014127T32 AA014127‐15R01 AA029700P50 AA022534Sanchez LMWallace DGSchaeffer EAAcosta GSavage DDOsterlund Oltmanns JRClark BJGoncalves Garcia MDonaldson TNDavies SfalseSexually dimorphic organization of open field behavior following moderate prenatal alcohol exposure.<h4>Background</h4>Prenatal alcohol exposure (PAE) can produce deficits in a wide range of cognitive functions but is especially detrimental to behaviors requiring accurate spatial information processing. In open field environments, spatial behavior is organized such that animals establish "home bases" marked by long stops focused around one location. Progressions away from the home base are circuitous and slow, while progressions directed toward the home base are non-circuitous and fast. The impact of PAE on the organization of open field behavior has not been experimentally investigated.<h4>Methods</h4>In the present study, adult female and male rats with moderate PAE or saccharin exposure locomoted a circular high walled open field for 30 minutes under lighted conditions.<h4>Results</h42022-01-01T00:00:00Z2022 May2025-04-04T09:18:59.901Z2025-04-04T09:18:59.901ZS-EPMC91174383531507510.1111/acer.14813