{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Molinari L"],"funding":["NIDDK NIH HHS","NIGMS NIH HHS"],"pagination":["e2212709"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9118077"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(5)"],"pubmed_abstract":["<h4>Importance</h4>The 23rd Acute Disease Quality Initiative (ADQI-23) consensus conference proposed a framework to integrate biomarkers into the staging of acute kidney injury (AKI). It is unknown whether tissue inhibitor of metalloproteinases 2 (TIMP-2) and insulinlike growth factor binding protein 7 (IGFBP7) could be used for staging.<h4>Objective</h4>To test whether higher levels of urinary [TIMP-2] × [IGFBP7] are associated with lower survival among patients with the same functional stage of AKI.<h4>Design, setting, and participants</h4>This cohort study was performed using data from the Protocolized Care for Early Septic Shock (ProCESS) trial, which enrolled critically ill patients with septic shock who presented at academic and community emergency departments and intensive care unit"],"journal":["JAMA network open"],"pubmed_title":["Utility of Biomarkers for Sepsis-Associated Acute Kidney Injury Staging."],"pmcid":["PMC9118077"],"funding_grant_id":["R01 DK083961","P50 GM076659"],"pubmed_authors":["ProCESS and ProGReSS-AKI Investigators","Terndrup T","Holmes TM","Ufberg JW","Miner JR","Hou PC","Nafeei S","Stapleton DK","Eaton TL","Brewer K","Edwards AR","LoVecchio F","Yende S","Weinert C","Carlson R","Rittenberger JS","Self WH","Wang HE","Willochell M","Landis K","Conrad SA","Wilson JW","Wadas RJ","Venkat A","Delbridge TR","Albertson T","Molinari L","Mainhart A","Grissom CK","Phillips CA","Yealy DM","Landsittel DP","Wojnar M","Parekh S","Palevsky PM","Gunn SR","Allen TL","Chawla LS","Orban DJ","Angus DC","Del Rio-Pertuz G","Sinert R","Lucko N","Swadron S","Singbartl K","Weissfeld LA","Huang DT","Bajwa EK","Gimbel E","Sama AE","Keener C","Limkakeng AT","Panacek EA","Dubinski D","Kelly M","Wofford KA","Pearl RG","McCurdy MT","Parmar S","Filbin MR","Pike F","Smith A","Fine J","Watts H","Barnato AE","Kulstad E","Wilber ST","Massaro A","Kellum JA","Parry BA","Harris ES","Ellender TJ","Migues RM"],"additional_accession":[]},"is_claimable":false,"name":"Utility of Biomarkers for Sepsis-Associated Acute Kidney Injury Staging.","description":"<h4>Importance</h4>The 23rd Acute Disease Quality Initiative (ADQI-23) consensus conference proposed a framework to integrate biomarkers into the staging of acute kidney injury (AKI). It is unknown whether tissue inhibitor of metalloproteinases 2 (TIMP-2) and insulinlike growth factor binding protein 7 (IGFBP7) could be used for staging.<h4>Objective</h4>To test whether higher levels of urinary [TIMP-2] × [IGFBP7] are associated with lower survival among patients with the same functional stage of AKI.<h4>Design, setting, and participants</h4>This cohort study was performed using data from the Protocolized Care for Early Septic Shock (ProCESS) trial, which enrolled critically ill patients with septic shock who presented at academic and community emergency departments and intensive care unit","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-26T15:25:00.805Z","creation":"2025-02-19T04:57:13.263Z"},"accession":"S-EPMC9118077","cross_references":{"pubmed":["35583867"],"doi":["10.1001/jamanetworkopen.2022.12709"]}}