{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(10)"],"submitter":["Lemaire ON"],"funding":["Max-Planck-Gesellschaft"],"pubmed_abstract":["Microbial anaerobic oxidation of alkanes intrigues the scientific community by way of its impact on the global carbon cycle, and its biotechnological applications. Archaea are proposed to degrade short- and long-chain alkanes to CO<sub>2</sub> by reversing methanogenesis, a theoretically reversible process. The pathway would start with alkane activation, an endergonic step catalyzed by methyl-coenzyme M reductase (MCR) homologues that would generate alkyl-thiols carried by coenzyme M. While the methane-generating MCR found in methanogens has been well characterized, the enzymatic activity of the putative alkane-fixing counterparts has not been validated so far. Such an absence of biochemical investigations contrasts with the current explosion of metagenomics data, which draws new potential"],"journal":["Biochemistry"],"pagination":["805-821"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9118554"],"repository":["biostudies-literature"],"pubmed_title":["A Structural View of Alkyl-Coenzyme M Reductases, the First Step of Alkane Anaerobic Oxidation Catalyzed by Archaea."],"pmcid":["PMC9118554"],"pubmed_authors":["Wagner T","Lemaire ON"],"additional_accession":[]},"is_claimable":false,"name":"A Structural View of Alkyl-Coenzyme M Reductases, the First Step of Alkane Anaerobic Oxidation Catalyzed by Archaea.","description":"Microbial anaerobic oxidation of alkanes intrigues the scientific community by way of its impact on the global carbon cycle, and its biotechnological applications. Archaea are proposed to degrade short- and long-chain alkanes to CO<sub>2</sub> by reversing methanogenesis, a theoretically reversible process. The pathway would start with alkane activation, an endergonic step catalyzed by methyl-coenzyme M reductase (MCR) homologues that would generate alkyl-thiols carried by coenzyme M. While the methane-generating MCR found in methanogens has been well characterized, the enzymatic activity of the putative alkane-fixing counterparts has not been validated so far. Such an absence of biochemical investigations contrasts with the current explosion of metagenomics data, which draws new potential","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-18T12:04:10.242Z","creation":"2025-04-05T20:39:43.833Z"},"accession":"S-EPMC9118554","cross_references":{"pubmed":["35500274"],"doi":["10.1021/acs.biochem.2c00135"]}}