biostudies-literatureCardenas CENIDCR NIH HHSNIBIB NIH HHSNCI NIH HHS426-436https://www.ebi.ac.uk/biostudies/studies/S-EPMC9119288biostudies-literatureUnknown113(2)<h4>Purpose</h4>Tumor and target volume manual delineation remains a challenging task in head and neck cancer radiation therapy. The purpose of this study was to conduct a multi-institutional evaluation of manual delineations of gross tumor volume (GTV), high-risk clinical target volume (CTV), parotids, and submandibular glands on treatment simulation magnetic resonance scans of patients with oropharyngeal cancer.<h4>Methods and materials</h4>We retrospectively collected pretreatment T1-weighted, T1-weighted with gadolinium contrast, and T2-weighted magnetic resonance imaging scans for 4 patients with oropharyngeal cancer under an institution review board-approved protocol. We provided the scans to 26 radiation oncologists from 7 international cancer centers that participated in this delinInternational journal of radiation oncology, biology, physicsComprehensive Quantitative Evaluation of Variability in Magnetic Resonance-Guided Delineation of Oropharyngeal Gross Tumor Volumes and High-Risk Clinical Target Volumes: An R-IDEAL Stage 0 Prospective Study.PMC9119288R01 CA218148F31 DE029093P30 CA016672P50 CA097007R01 DE025248R01 DE028290R01 CA214825R25 EB025787R56 DE025248R01 CA257814Al-Mamgani AAMohamed ASRCardenas CETerhaard CPhilippens MFuller CDNewbold KBlinde SEKotte ARaaijmakers CKaram IThomson DJRobbins JNg SPfalseComprehensive Quantitative Evaluation of Variability in Magnetic Resonance-Guided Delineation of Oropharyngeal Gross Tumor Volumes and High-Risk Clinical Target Volumes: An R-IDEAL Stage 0 Prospective Study.<h4>Purpose</h4>Tumor and target volume manual delineation remains a challenging task in head and neck cancer radiation therapy. The purpose of this study was to conduct a multi-institutional evaluation of manual delineations of gross tumor volume (GTV), high-risk clinical target volume (CTV), parotids, and submandibular glands on treatment simulation magnetic resonance scans of patients with oropharyngeal cancer.<h4>Methods and materials</h4>We retrospectively collected pretreatment T1-weighted, T1-weighted with gadolinium contrast, and T2-weighted magnetic resonance imaging scans for 4 patients with oropharyngeal cancer under an institution review board-approved protocol. We provided the scans to 26 radiation oncologists from 7 international cancer centers that participated in this delin2022-01-01T00:00:00Z2022 Jun2025-04-26T22:56:22.025Z2025-04-06T17:25:41.917ZS-EPMC91192883512413410.1016/j.ijrobp.2022.01.050