{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Milenkovic D"],"funding":["Swedish State","German Center for Diabetes Research","European Research Council","Swedish Cancer Foundation","Knut och Alice Wallenbergs Stiftelse","Diabetesfonden","Swedish Research Council","Novo Nordisk Fonden","German Federal Ministry of Education and Research"],"pagination":["e1010190"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9119528"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(5)"],"pubmed_abstract":["Mitochondrial DNA (mtDNA) maintenance disorders are caused by mutations in ubiquitously expressed nuclear genes and lead to syndromes with variable disease severity and tissue-specific phenotypes. Loss of function mutations in the gene encoding the mitochondrial genome and maintenance exonuclease 1 (MGME1) result in deletions and depletion of mtDNA leading to adult-onset multisystem mitochondrial disease in humans. To better understand the in vivo function of MGME1 and the associated disease pathophysiology, we characterized a Mgme1 mouse knockout model by extensive phenotyping of ageing knockout animals. We show that loss of MGME1 leads to de novo formation of linear deleted mtDNA fragments that are constantly made and degraded. These findings contradict previous proposal that MGME1 is es"],"journal":["PLoS genetics"],"pubmed_title":["Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction."],"pmcid":["PMC9119528"],"funding_grant_id":["741366","NNF20OC0063616","SLL2018.0471","Infrafrontier grant 01KX1012","2015-00418","2016-741366","DIA2020-516","2021.1409"],"pubmed_authors":["Gerlini R","Calzada-Wack J","Larsson NG","Veronica Amarie O","Misic J","Simard ML","Gailus-Durner V","de Angelis MH","Wolf E","Rathkolb B","Fuchs H","Milenkovic D","Sanz-Moreno A","Aguilar-Pimentel A"],"additional_accession":[]},"is_claimable":false,"name":"Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.","description":"Mitochondrial DNA (mtDNA) maintenance disorders are caused by mutations in ubiquitously expressed nuclear genes and lead to syndromes with variable disease severity and tissue-specific phenotypes. Loss of function mutations in the gene encoding the mitochondrial genome and maintenance exonuclease 1 (MGME1) result in deletions and depletion of mtDNA leading to adult-onset multisystem mitochondrial disease in humans. To better understand the in vivo function of MGME1 and the associated disease pathophysiology, we characterized a Mgme1 mouse knockout model by extensive phenotyping of ageing knockout animals. We show that loss of MGME1 leads to de novo formation of linear deleted mtDNA fragments that are constantly made and degraded. These findings contradict previous proposal that MGME1 is es","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-09T18:56:26.187Z","creation":"2025-04-05T20:39:58.352Z"},"accession":"S-EPMC9119528","cross_references":{"pubmed":["35533204"],"doi":["10.1371/journal.pgen.1010190"]}}