{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Niroomand A"],"funding":["Marianne and Marcus Wallenberg Foundation","ALF Foundation","Knut and Alice Wallenberg Foundation","Wallenberg Molecular Medicine Fellowship","Lund University"],"pubmed_abstract":["Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft. There is great clinical need for a minimally invasive biomarker of BOS. Here, 644 different proteins were analyzed to detect biomarkers that distinguish BOS grade 0 from grades 1-3. The plasma of 46 double lung transplant patients was analyzed for proteins using a high-component, multiplex immunoassay that enables analysis of protein biomarkers. Proximity Extension Assay (PEA) consists of antibody probe pairs which bind to targets. The resulting polymerase chain reaction (PCR) reporter sequence can be quantified by real-time PCR. Samples were collected at baseline and 1-year post trans"],"journal":["Scientific reports"],"pagination":["8413"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9120482"],"repository":["biostudies-literature"],"pubmed_title":["Corticotropin releasing hormone as an identifier of bronchiolitis obliterans syndrome."],"pmcid":["PMC9120482"],"pubmed_authors":["Wagner D","Mackova M","Hallgren O","Hansson L","Halloran K","Niroomand A","Lindstedt S","Larsson H","Ghaidan H","Hyllen S"],"additional_accession":[]},"is_claimable":false,"name":"Corticotropin releasing hormone as an identifier of bronchiolitis obliterans syndrome.","description":"Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft. There is great clinical need for a minimally invasive biomarker of BOS. Here, 644 different proteins were analyzed to detect biomarkers that distinguish BOS grade 0 from grades 1-3. The plasma of 46 double lung transplant patients was analyzed for proteins using a high-component, multiplex immunoassay that enables analysis of protein biomarkers. Proximity Extension Assay (PEA) consists of antibody probe pairs which bind to targets. The resulting polymerase chain reaction (PCR) reporter sequence can be quantified by real-time PCR. Samples were collected at baseline and 1-year post trans","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-18T12:04:46.918Z","creation":"2025-04-05T20:38:30.256Z"},"accession":"S-EPMC9120482","cross_references":{"pubmed":["35589861"],"doi":["10.1038/s41598-022-12546-1"]}}