biostudies-literatureKamps FSNEI NIH HHSNICHD NIH HHSNational Eye InstituteSimons Foundation Autism Research InitiativeNIMH NIH HHSNational Institute of Mental HealthDavid and Lucile Packard Foundation2782-2800https://www.ebi.ac.uk/biostudies/studies/S-EPMC9120553biostudies-literatureUnknown43(9)Scanning young children while they watch short, engaging, commercially-produced movies has emerged as a promising approach for increasing data retention and quality. Movie stimuli also evoke a richer variety of cognitive processes than traditional experiments, allowing the study of multiple aspects of brain development simultaneously. However, because these stimuli are uncontrolled, it is unclear how effectively distinct profiles of brain activity can be distinguished from the resulting data. Here we develop an approach for identifying multiple distinct subject-specific Regions of Interest (ssROIs) using fMRI data collected during movie-viewing. We focused on the test case of higher-level visual regions selective for faces, scenes, and objects. Adults (N = 13) were scanned while viewing a Human brain mappingUsing child-friendly movie stimuli to study the development of face, place, and object regions from age 3 to 12 years.PMC9120553R01 MH096914R01‐MH096914‐05R01 EY033843DP1 HD0919472008‐333024K99 EY0326031K99EY032603R01 HD103847Kamps FSKanwisher NSaxe RRichardson HMurty NARfalseUsing child-friendly movie stimuli to study the development of face, place, and object regions from age 3 to 12 years.Scanning young children while they watch short, engaging, commercially-produced movies has emerged as a promising approach for increasing data retention and quality. Movie stimuli also evoke a richer variety of cognitive processes than traditional experiments, allowing the study of multiple aspects of brain development simultaneously. However, because these stimuli are uncontrolled, it is unclear how effectively distinct profiles of brain activity can be distinguished from the resulting data. Here we develop an approach for identifying multiple distinct subject-specific Regions of Interest (ssROIs) using fMRI data collected during movie-viewing. We focused on the test case of higher-level visual regions selective for faces, scenes, and objects. Adults (N = 13) were scanned while viewing a 2022-01-01T00:00:00Z2022 Jun2026-06-04T04:35:04.986Z2024-11-09T12:04:25.995ZS-EPMC91205533527478910.1002/hbm.25815