{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["46(3)"],"submitter":["Lee JO"],"funding":["Konkuk University"],"pubmed_abstract":["<h4>Background</h4>Although ginsenosides and saponins in Korea red ginseng (KRG) shows various pharmacological roles, their roles in the inflammatory response are little known. This study investigated the anti-inflammatory role of ginsenosides identified from KRG saponin fraction (RGSF) and the potential mechanism in macrophages.<h4>Methods</h4>The ginsenoside composition of RGSF was identified by high-performance liquid chromatography (HPLC) analysis. An anti-inflammatory effect of RGSF and its mechanisms were studied using nitric oxide (NO) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) production assays, mRNA expression analyses of inflammatory genes and cytokines, luciferase reporter gene assays of transcription factors, and Western blot analyses of inflammatory signaling pathways u"],"journal":["Journal of ginseng research"],"pagination":["489-495"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9120761"],"repository":["biostudies-literature"],"pubmed_title":["Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways."],"pmcid":["PMC9120761"],"pubmed_authors":["Yang Y","Lee JO","Cho JY","Tao Y","Yi YS"],"additional_accession":[]},"is_claimable":false,"name":"Korean Red Ginseng saponin fraction exerts anti-inflammatory effects by targeting the NF-κB and AP-1 pathways.","description":"<h4>Background</h4>Although ginsenosides and saponins in Korea red ginseng (KRG) shows various pharmacological roles, their roles in the inflammatory response are little known. This study investigated the anti-inflammatory role of ginsenosides identified from KRG saponin fraction (RGSF) and the potential mechanism in macrophages.<h4>Methods</h4>The ginsenoside composition of RGSF was identified by high-performance liquid chromatography (HPLC) analysis. An anti-inflammatory effect of RGSF and its mechanisms were studied using nitric oxide (NO) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) production assays, mRNA expression analyses of inflammatory genes and cytokines, luciferase reporter gene assays of transcription factors, and Western blot analyses of inflammatory signaling pathways u","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-05T15:52:15.605Z","creation":"2025-04-05T15:52:15.605Z"},"accession":"S-EPMC9120761","cross_references":{"pubmed":["35600780"],"doi":["10.1016/j.jgr.2022.02.004"]}}