biostudies-literatureUnknown10Po' C<h4>Background</h4>Moyamoya is a rare progressive cerebral arteriopathy, occurring as an isolated phenomenon (moyamoya disease, MMD) or associated with other conditions (moyamoya syndrome, MMS), responsible for 6-10% of all childhood strokes and transient ischemic attacks (TIAs).<h4>Methods</h4>We conducted a retrospective multicenter study on pediatric-onset MMD/MMS in Italy in order to characterize disease presentation, course, management, neuroradiology, and outcome in a European country.<h4>Results</h4>A total of 65 patients (34/65 women) with MMD (27/65) or MMS (38/65) were included. About 18% (12/65) of patients were asymptomatic and diagnosed incidentally during investigations performed for an underlying condition (incMMS), whereas 82% (53/65) of patients with MMD or MMS were diagnoFrontiers in pediatrics892445https://www.ebi.ac.uk/biostudies/studies/S-EPMC9120837biostudies-literaturePediatric Moyamoya Disease and Syndrome in Italy: A Multicenter Cohort.PMC9120837Ragazzi PGiordano LMorini GScelsa BSanfilippo GLafe EColombatti RThyrion FZPo' CMartelli PMirone GPolonara GRaviglione FToni FZedde MMarras CECirillo LDi Rosa GCordelli DMNicita FCosi ASartori SFoiadelli TManara RToldo IPruna DSpalice ALanterna LASainati LBaro VOperto FFSuppiej ACarai ANosadini MDe Carlo LAzzolina DBova SMRollo MPascarella RCesaroni EEsposito GFrigo ACGrazian LSavasta SCampa SAccorsi PIodice ACicala DGreco FStriano PAgostini MSkabar ARosati ACausin FfalsePediatric Moyamoya Disease and Syndrome in Italy: A Multicenter Cohort.<h4>Background</h4>Moyamoya is a rare progressive cerebral arteriopathy, occurring as an isolated phenomenon (moyamoya disease, MMD) or associated with other conditions (moyamoya syndrome, MMS), responsible for 6-10% of all childhood strokes and transient ischemic attacks (TIAs).<h4>Methods</h4>We conducted a retrospective multicenter study on pediatric-onset MMD/MMS in Italy in order to characterize disease presentation, course, management, neuroradiology, and outcome in a European country.<h4>Results</h4>A total of 65 patients (34/65 women) with MMD (27/65) or MMS (38/65) were included. About 18% (12/65) of patients were asymptomatic and diagnosed incidentally during investigations performed for an underlying condition (incMMS), whereas 82% (53/65) of patients with MMD or MMS were diagno2022-01-01T00:00:00Z20222025-05-29T19:23:07.706Z2025-05-29T19:23:07.706ZS-EPMC91208373560141110.3389/fped.2022.892445