{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gideon HP"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS","Wellcome Trust","NIGMS NIH HHS"],"pagination":["827-846.e10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9122264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(5)"],"pubmed_abstract":["Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance. Bacterial persistence occurred in granulomas enriched for mast, endothelial, fibroblast, and plasma cells, signaling amongst themselves via type 2 immunity and wound-healing pathways. Granulomas that drove bacterial control were characterized by cellular ecosystems enriched for type 1-type 17, stem-like, and cytotoxic T cells engaged in pro-infl"],"journal":["Immunity"],"pubmed_title":["Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control."],"pmcid":["PMC9122264"],"funding_grant_id":["T32 GM087237","R01 AI022553","P30 AI060354","210662/Z/16/Z","U01 HL157004","K12 HL143886","P30 CA014051","U24 AI118672","T32 AI007387","F30 AI143160","T32 AI065380"],"pubmed_authors":["Flynn JL","Behar SM","Myers A","Ameel CL","Fortune SM","Tomko JA","Cochran CT","Madansein R","White AG","Hopkins FF","Nargan K","Chao M","Peters JM","Maiello P","Hughes TK","Tzouanas CN","Bryson B","Leslie A","Grant NL","Berger B","Lin PL","Ganchua SKC","Ordovas-Montanes J","Wadsworth MH","Tu AA","Scanga CA","Gideon HP","Mattila JT","Patel KV","Rosenberg JM","Nyquist SK","Klein E","Frye LJ","Shalek AK","Borish HJ","Love JC","Wei JR","Phuah JY","Shih A","Winchell CG","Ibrahim S","Gierahn TM","Kummerlowe C"],"additional_accession":[]},"is_claimable":false,"name":"Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control.","description":"Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance. Bacterial persistence occurred in granulomas enriched for mast, endothelial, fibroblast, and plasma cells, signaling amongst themselves via type 2 immunity and wound-healing pathways. Granulomas that drove bacterial control were characterized by cellular ecosystems enriched for type 1-type 17, stem-like, and cytotoxic T cells engaged in pro-infl","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-10T01:38:56.771Z","creation":"2025-02-19T01:12:31.689Z"},"accession":"S-EPMC9122264","cross_references":{"pubmed":["35483355"],"doi":["10.1016/j.immuni.2022.04.004"]}}