{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(5)"],"submitter":["Sun Y"],"pubmed_abstract":["Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3 that functions as a transcriptional co-regulator. In this study, we demonstrate that PHF13 is required for pancreatic-cancer-cell growth and metastasis. Integrative analysis of transcriptome and epigenetic profiles provide further mechanistic insights into the epigenetic regulation of genes associated with cell metastasis during the epithelial-to-mesenchymal transition (EMT) induced by transforming growth factor β (TGFβ). Our data suggest PHF13 depletion impairs activation of TGFβ stimulated genes and correlates with a loss of active epigenetic marks (H3K4me3 and H3K27ac) at these genomic regions. These observations argue for a dependency of TGFβ target activation on PHF13. Furthermore, PHF13-dependent chromatin regions are enriched in broad H3K4me3 domains and super-enhancers, which control genes critical to cancer-cell migration and invasion, such as SNAI1 and SOX9. Overall, our data indicate a functional and mechanistic correlation between PHF13 and EMT."],"journal":["Cell death & disease"],"pagination":["487"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9124206"],"repository":["biostudies-literature"],"pubmed_title":["PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition."],"pmcid":["PMC9124206"],"pubmed_authors":["Liu H","Meng F","Tang J","Xie W","Li Z","Huang Y","Li D","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition.","description":"Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3 that functions as a transcriptional co-regulator. In this study, we demonstrate that PHF13 is required for pancreatic-cancer-cell growth and metastasis. Integrative analysis of transcriptome and epigenetic profiles provide further mechanistic insights into the epigenetic regulation of genes associated with cell metastasis during the epithelial-to-mesenchymal transition (EMT) induced by transforming growth factor β (TGFβ). Our data suggest PHF13 depletion impairs activation of TGFβ stimulated genes and correlates with a loss of active epigenetic marks (H3K4me3 and H3K27ac) at these genomic regions. These observations argue for a dependency of TGFβ target activation on PHF13. Furthermore, PHF13-dependent chromatin regions are enriched in broad H3K4me3 domains and super-enhancers, which control genes critical to cancer-cell migration and invasion, such as SNAI1 and SOX9. Overall, our data indicate a functional and mechanistic correlation between PHF13 and EMT.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2024-12-03T16:05:01.414Z","creation":"2024-12-03T16:05:01.414Z"},"accession":"S-EPMC9124206","cross_references":{"pubmed":["35597793"],"doi":["10.1038/s41419-022-04940-4"]}}