biostudies-literatureUnknown15(1)Sedighiyan M<h4>Objective</h4>The present study aimed to investigate the effects of nano-curcumin supplementation on adipokines levels and clinical signs in obese and overweight patients with migraine.<h4>Results</h4>Forty-four patients with episodic migraine participated in this clinical trial and were divided into two groups nano-curcumin (80 mg/day) and the control group over 2-month period. At the baseline and the end of the research, the serum levels of MCP-1, Resistin, and Visfatin were measured using the ELISA method. In addition, the headache attack frequencies, severity, and duration of pain were recorded. The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). In the case BMC research notes189https://www.ebi.ac.uk/biostudies/studies/S-EPMC9125853biostudies-literatureThe effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study.PMC9125853Jafari EDjalali MSohrabi Athar SSedighiyan MAbdolahi MVahabi ZYekaninejad MSNarimani Zamanabadi MHadavi SfalseThe effects of nano-curcumin supplementation on adipokines levels in obese and overweight patients with migraine: a double blind clinical trial study.<h4>Objective</h4>The present study aimed to investigate the effects of nano-curcumin supplementation on adipokines levels and clinical signs in obese and overweight patients with migraine.<h4>Results</h4>Forty-four patients with episodic migraine participated in this clinical trial and were divided into two groups nano-curcumin (80 mg/day) and the control group over 2-month period. At the baseline and the end of the research, the serum levels of MCP-1, Resistin, and Visfatin were measured using the ELISA method. In addition, the headache attack frequencies, severity, and duration of pain were recorded. The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). In the case 2022-01-01T00:00:00Z2022 May2025-04-22T03:51:00.635Z2025-02-19T01:24:05.431ZS-EPMC91258533560688210.1186/s13104-022-06074-4