{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Islam MT"],"funding":["Naito Foundation","Kao Research Council for the Study of Healthcare Science","Takeda Science Foundation","Kanazawa University CHOZEN project","MEXT Japanese Government Scholarship for International Students","Daiichi Sankyo Foundation of Life Science"],"pubmed_abstract":["Self-grooming plays an essential role in hygiene maintenance, thermoregulation, and stress response. However, the neural populations involved in self-grooming remain largely unknown. The paraventricular hypothalamic nucleus (PVH) has been implicated in the regulation of self-grooming. Arginine vasopressin-producing neurons are among the major neuronal populations in the PVH (PVH<sup>AVP</sup>), which play important roles in water homeostasis, blood pressure regulation, feeding, and stress response. Here, we report the critical role of PVH<sup>AVP</sup> neurons in the induction of self-grooming. Optogenetic activation of PVH<sup>AVP</sup> neurons immediately induced self-grooming in freely moving mice. Chemogenetic activation of these neurons also increased time spent self-grooming. In cont"],"journal":["Molecular brain"],"pagination":["47"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9125887"],"repository":["biostudies-literature"],"pubmed_title":["Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice."],"pmcid":["PMC9125887"],"pubmed_authors":["Maejima T","Mieda M","Matsui A","Islam MT"],"additional_accession":[]},"is_claimable":false,"name":"Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice.","description":"Self-grooming plays an essential role in hygiene maintenance, thermoregulation, and stress response. However, the neural populations involved in self-grooming remain largely unknown. The paraventricular hypothalamic nucleus (PVH) has been implicated in the regulation of self-grooming. Arginine vasopressin-producing neurons are among the major neuronal populations in the PVH (PVH<sup>AVP</sup>), which play important roles in water homeostasis, blood pressure regulation, feeding, and stress response. Here, we report the critical role of PVH<sup>AVP</sup> neurons in the induction of self-grooming. Optogenetic activation of PVH<sup>AVP</sup> neurons immediately induced self-grooming in freely moving mice. Chemogenetic activation of these neurons also increased time spent self-grooming. In cont","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-22T13:08:33.837Z","creation":"2025-02-19T04:56:46.641Z"},"accession":"S-EPMC9125887","cross_references":{"pubmed":["35606816"],"doi":["10.1186/s13041-022-00932-9"]}}