{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Sun Q"],"pubmed_abstract":["<h4>Purpose</h4>To investigate the expression of LPCAT1 in liver hepatocellular carcinoma (LIHC) and its relationship with prognosis and immune infiltration and predict its upstream nonencoding RNAs (ncRNAs).<h4>Method</h4>In this study, expression analysis and survival analysis for LPCAT1 in pan cancers were first performed by using The Cancer Genome Atlas (TCGA) data, which suggested that LPCAT1 might be a potential LIHC oncogene. Then, ncRNAs contributing to the overexpression of LPCAT1 were explored in starBase by a combination of expression analysis, correlation analysis, and survival analysis. Immune cell infiltration of LPCAT1 in LIHC was finally investigated via Tumor Immune Estimation Resource (TIMER).<h4>Result</h4>SNHG3 was observed to be the most promising upstream lncRNA for t"],"journal":["Journal of immunology research"],"pagination":["1584397"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9126685"],"repository":["biostudies-literature"],"pubmed_title":["ncRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immune Infiltration of Liver Hepatocellular Carcinoma."],"pmcid":["PMC9126685"],"pubmed_authors":["Liu X","Sun Q","Jiang X","Peng Q","Hu L"],"additional_accession":[]},"is_claimable":false,"name":"ncRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immune Infiltration of Liver Hepatocellular Carcinoma.","description":"<h4>Purpose</h4>To investigate the expression of LPCAT1 in liver hepatocellular carcinoma (LIHC) and its relationship with prognosis and immune infiltration and predict its upstream nonencoding RNAs (ncRNAs).<h4>Method</h4>In this study, expression analysis and survival analysis for LPCAT1 in pan cancers were first performed by using The Cancer Genome Atlas (TCGA) data, which suggested that LPCAT1 might be a potential LIHC oncogene. Then, ncRNAs contributing to the overexpression of LPCAT1 were explored in starBase by a combination of expression analysis, correlation analysis, and survival analysis. Immune cell infiltration of LPCAT1 in LIHC was finally investigated via Tumor Immune Estimation Resource (TIMER).<h4>Result</h4>SNHG3 was observed to be the most promising upstream lncRNA for t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T01:16:43.863Z","creation":"2025-02-19T04:30:18.207Z"},"accession":"S-EPMC9126685","cross_references":{"pubmed":["35615532"],"doi":["10.1155/2022/1584397"]}}