biostudies-literatureUnknown2022Sun Q<h4>Purpose</h4>To investigate the expression of LPCAT1 in liver hepatocellular carcinoma (LIHC) and its relationship with prognosis and immune infiltration and predict its upstream nonencoding RNAs (ncRNAs).<h4>Method</h4>In this study, expression analysis and survival analysis for LPCAT1 in pan cancers were first performed by using The Cancer Genome Atlas (TCGA) data, which suggested that LPCAT1 might be a potential LIHC oncogene. Then, ncRNAs contributing to the overexpression of LPCAT1 were explored in starBase by a combination of expression analysis, correlation analysis, and survival analysis. Immune cell infiltration of LPCAT1 in LIHC was finally investigated via Tumor Immune Estimation Resource (TIMER).<h4>Result</h4>SNHG3 was observed to be the most promising upstream lncRNA for tJournal of immunology research1584397https://www.ebi.ac.uk/biostudies/studies/S-EPMC9126685biostudies-literaturencRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immune Infiltration of Liver Hepatocellular Carcinoma.PMC9126685Liu XSun QJiang XPeng QHu LfalsencRNA-Mediated High Expression of LPCAT1 Correlates with Poor Prognosis and Tumor Immune Infiltration of Liver Hepatocellular Carcinoma.<h4>Purpose</h4>To investigate the expression of LPCAT1 in liver hepatocellular carcinoma (LIHC) and its relationship with prognosis and immune infiltration and predict its upstream nonencoding RNAs (ncRNAs).<h4>Method</h4>In this study, expression analysis and survival analysis for LPCAT1 in pan cancers were first performed by using The Cancer Genome Atlas (TCGA) data, which suggested that LPCAT1 might be a potential LIHC oncogene. Then, ncRNAs contributing to the overexpression of LPCAT1 were explored in starBase by a combination of expression analysis, correlation analysis, and survival analysis. Immune cell infiltration of LPCAT1 in LIHC was finally investigated via Tumor Immune Estimation Resource (TIMER).<h4>Result</h4>SNHG3 was observed to be the most promising upstream lncRNA for t2022-01-01T00:00:00Z20222025-04-22T01:16:43.863Z2025-02-19T04:30:18.207ZS-EPMC91266853561553210.1155/2022/1584397