{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Liu Z"],"pubmed_abstract":["Thyroid associated ophthalmopathy (TAO), characterized by T cell infiltration and orbital fibroblast activation, is an organ-specific autoimmune disease which is still short of effective and safety therapeutic drugs. The PD-1/PD-L1 pathway has been reported hindering the progression of Graves' disease to some extent by inhibiting T cell activity, and tumor therapy with a PD-1 inhibitor caused some adverse effects similar to the symptoms of TAO. These findings suggest that the PD-1/PD-L1 pathway may be associated with the pathogenesis of TAO. However, it remains unknown whether the PD-1/PD-L1 pathway is involved in orbital fibroblast activation. Here, we show that orbital fibroblasts from patients with TAO do not express PD-L1. Based on <i>in vitro</i> OF-T cell co-culture system, exogenous"],"journal":["Frontiers in immunology"],"pagination":["849480"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9128409"],"repository":["biostudies-literature"],"pubmed_title":["PD-L1 Inhibits T Cell-Induced Cytokines and Hyaluronan Expression <i>via</i> the CD40-CD40L Pathway in Orbital Fibroblasts From Patients With Thyroid Associated Ophthalmopathy."],"pmcid":["PMC9128409"],"pubmed_authors":["Liu Y","Li X","Liu Z","Liu M","Gong Q","Guan X","Shi A","Hao B","Yuan H","Bai X","Zhou X","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"PD-L1 Inhibits T Cell-Induced Cytokines and Hyaluronan Expression <i>via</i> the CD40-CD40L Pathway in Orbital Fibroblasts From Patients With Thyroid Associated Ophthalmopathy.","description":"Thyroid associated ophthalmopathy (TAO), characterized by T cell infiltration and orbital fibroblast activation, is an organ-specific autoimmune disease which is still short of effective and safety therapeutic drugs. The PD-1/PD-L1 pathway has been reported hindering the progression of Graves' disease to some extent by inhibiting T cell activity, and tumor therapy with a PD-1 inhibitor caused some adverse effects similar to the symptoms of TAO. These findings suggest that the PD-1/PD-L1 pathway may be associated with the pathogenesis of TAO. However, it remains unknown whether the PD-1/PD-L1 pathway is involved in orbital fibroblast activation. Here, we show that orbital fibroblasts from patients with TAO do not express PD-L1. Based on <i>in vitro</i> OF-T cell co-culture system, exogenous","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T21:50:23.481Z","creation":"2025-02-19T01:23:42.496Z"},"accession":"S-EPMC9128409","cross_references":{"pubmed":["35619700"],"doi":["10.3389/fimmu.2022.849480"]}}