{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mellis AM"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","Centers for Disease Control and Prevention","National Institute for Allergy and Infectious Diseases","NIAID NIH HHS","NCIRD CDC HHS","CDC HHS"],"pagination":["1699-1703"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9129201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["226(10)"],"pubmed_abstract":["We used daily real-time reverse-transcription polymerase chain reaction (RT-PCR) results from 67 cases of SARS-CoV-2 infection in a household transmission study, conducted April 2020-May 2021, to examine the trajectory of cycle threshold (Ct) values, an inverse correlate of viral RNA concentration. Ct values varied across RT-PCR platforms and by participant age. Specimens collected from children and adolescents had higher Ct values and adults aged ≥50 years showed lower Ct values than adults aged 18-49 years. Ct values were lower on days when participants reported experiencing symptoms, with the lowest Ct value occurring 2-6 days after symptom onset."],"journal":["The Journal of infectious diseases"],"pubmed_title":["SARS-CoV-2 Virus Dynamics in Recently Infected People-Data From a Household Transmission Study."],"pmcid":["PMC9129201"],"funding_grant_id":["U01 IP001078","K24 AI148459","UL1 TR002243-03","IP001078","IP001083"],"pubmed_authors":["Halasa NB","Grijalva CG","Ivacic LC","Kim A","Zhu Y","Deyoe J","Chappell JD","Talbot HK","McLean HQ","Rolfes MA","Hanson KE","Meece JK","Reed C","Mellis AM"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 Virus Dynamics in Recently Infected People-Data From a Household Transmission Study.","description":"We used daily real-time reverse-transcription polymerase chain reaction (RT-PCR) results from 67 cases of SARS-CoV-2 infection in a household transmission study, conducted April 2020-May 2021, to examine the trajectory of cycle threshold (Ct) values, an inverse correlate of viral RNA concentration. Ct values varied across RT-PCR platforms and by participant age. Specimens collected from children and adolescents had higher Ct values and adults aged ≥50 years showed lower Ct values than adults aged 18-49 years. Ct values were lower on days when participants reported experiencing symptoms, with the lowest Ct value occurring 2-6 days after symptom onset.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T22:12:35.913Z","creation":"2025-02-19T03:58:28.367Z"},"accession":"S-EPMC9129201","cross_references":{"pubmed":["35512334"],"doi":["10.1093/infdis/jiac180"]}}