biostudies-literatureSun HNational Natural Science Foundation of ChinaInner Mongolia Science & Technology Major ProjectsNational Natural Science Foundation of China (National Science Foundation of China)62https://www.ebi.ac.uk/biostudies/studies/S-EPMC9130297biostudies-literatureUnknown8(1)Parkinson's disease (PD) is mainly managed by pharmacological therapy (e.g., Benserazide and dopamine agonists). However, prolonged use of these drugs would gradually diminish their dopaminergic effect. Gut dysbiosis was observed in some patients with PD, suggesting close association between the gut microbiome and PD. Probiotics modulate the host's gut microbiota beneficially. A 3-month randomized, double-blind, placebo-controlled clinical trial was conducted to investigate the beneficial effect of probiotic co-administration in patients with PD. Eighty-two PD patients were recruited and randomly divided into probiotic [n = 48; Bifidobacterium animalis subsp. lactis Probio-M8 (Probio-M8), Benserazide, dopamine agonists] and placebo (n = 34; placebo, Benserazide, dopamine agonists) groups. NPJ Parkinson's diseaseProbiotics synergized with conventional regimen in managing Parkinson's disease.PMC913029731720103911Zhang JLeng BLi FZhang HQuan KMa TZhang SSun ZLiu YJin HLi ZKwok LYZhao FSun HYuan XZhao JfalseProbiotics synergized with conventional regimen in managing Parkinson's disease.Parkinson's disease (PD) is mainly managed by pharmacological therapy (e.g., Benserazide and dopamine agonists). However, prolonged use of these drugs would gradually diminish their dopaminergic effect. Gut dysbiosis was observed in some patients with PD, suggesting close association between the gut microbiome and PD. Probiotics modulate the host's gut microbiota beneficially. A 3-month randomized, double-blind, placebo-controlled clinical trial was conducted to investigate the beneficial effect of probiotic co-administration in patients with PD. Eighty-two PD patients were recruited and randomly divided into probiotic [n = 48; Bifidobacterium animalis subsp. lactis Probio-M8 (Probio-M8), Benserazide, dopamine agonists] and placebo (n = 34; placebo, Benserazide, dopamine agonists) groups. 2022-01-01T00:00:00Z2022 May2025-04-26T15:24:49.961Z2025-02-19T04:56:41.744ZS-EPMC91302973561023610.1038/s41531-022-00327-6