biostudies-literatureKnitza JUniversitätsklinikum ErlangenThermo Fisher Scientific, Freiburg, GermanyDeutsche Forschungsgemeinschaft125https://www.ebi.ac.uk/biostudies/studies/S-EPMC9130452biostudies-literatureUnknown24(1)<h4>Background</h4>Rheumatoid arthritis (RA) requires early diagnosis and tight surveillance of disease activity. Remote self-collection of blood for the analysis of inflammation markers and autoantibodies could improve the monitoring of RA and facilitate the identification of individuals at-risk for RA.<h4>Objective</h4>Randomized, controlled trial to evaluate the accuracy, feasibility, and acceptability of an upper arm self-sampling device (UA) and finger prick-test (FP) to measure capillary blood from RA patients for C-reactive protein (CRP) levels and the presence of IgM rheumatoid factor (RF IgM) and anti-cyclic citrullinated protein antibodies (anti-CCP IgG).<h4>Methods</h4>RA patients were randomly assigned in a 1:1 ratio to self-collection of capillary blood via UA or FP. Venous blArthritis research & therapyAccuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients-results from a randomized controlled trial.PMC91304522886Aubourg TMatusewicz PKleyer ABendzuck GBoeltz SHueber AJKronke GKnitza JEimer EKorinth MVuillerme NCorte GElling-Audersch CSchett GSimon DSchuster LTascilar KfalseAccuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients-results from a randomized controlled trial.<h4>Background</h4>Rheumatoid arthritis (RA) requires early diagnosis and tight surveillance of disease activity. Remote self-collection of blood for the analysis of inflammation markers and autoantibodies could improve the monitoring of RA and facilitate the identification of individuals at-risk for RA.<h4>Objective</h4>Randomized, controlled trial to evaluate the accuracy, feasibility, and acceptability of an upper arm self-sampling device (UA) and finger prick-test (FP) to measure capillary blood from RA patients for C-reactive protein (CRP) levels and the presence of IgM rheumatoid factor (RF IgM) and anti-cyclic citrullinated protein antibodies (anti-CCP IgG).<h4>Methods</h4>RA patients were randomly assigned in a 1:1 ratio to self-collection of capillary blood via UA or FP. Venous bl2022-01-01T00:00:00Z2022 May2026-06-04T07:59:09.449Z2024-11-11T23:02:04.85ZS-EPMC91304523561448810.1186/s13075-022-02809-7