{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Li Q"],"pubmed_abstract":["Ovarian cancer is a common malignancy with a mortality and effective, efficient treatments are urgently needed. Myricetin (Myr) is a flavonoid with antioxidant and anticancer properties. Here, we assessed Myr's toxicity on the non-tumor cell line, IOSE-80 and the mechanism by which it suppresses proliferation, migration, and invasion of ovarian cancer SKOV3 cells. The effects of Myr on SKOV3 cells were assessed using CCK-8, oxidative stress, wound healing, Transwell, Hoechst 33258 staining, and western blot assays. Our data show that although Myr was not toxic against IOSE-80 cells for a range of concentrations 0-40μM, it suppressed SKOV3 cell proliferation, migration, and invasion and enhanced apoptosis. Mechanistically, it activated the p38/Sapla signaling pathway, thereby inhibiting oxidative stress and reducing the level of ROS in tumor cells. Our data show that Myr suppresses ovarian cancer cells <i>in vitro</i> and suggests Myr as a candidate agent against ovarian cancer."],"journal":["Frontiers in oncology"],"pagination":["903394"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9130763"],"repository":["biostudies-literature"],"pubmed_title":["Myricetin Suppresses Ovarian Cancer <i>In Vitro</i> by Activating the p38/Sapla Signaling Pathway and Suppressing Intracellular Oxidative Stress."],"pmcid":["PMC9130763"],"pubmed_authors":["Ma Y","Li Q","Gu Z","Chen S","Tan Q"],"additional_accession":[]},"is_claimable":false,"name":"Myricetin Suppresses Ovarian Cancer <i>In Vitro</i> by Activating the p38/Sapla Signaling Pathway and Suppressing Intracellular Oxidative Stress.","description":"Ovarian cancer is a common malignancy with a mortality and effective, efficient treatments are urgently needed. Myricetin (Myr) is a flavonoid with antioxidant and anticancer properties. Here, we assessed Myr's toxicity on the non-tumor cell line, IOSE-80 and the mechanism by which it suppresses proliferation, migration, and invasion of ovarian cancer SKOV3 cells. The effects of Myr on SKOV3 cells were assessed using CCK-8, oxidative stress, wound healing, Transwell, Hoechst 33258 staining, and western blot assays. Our data show that although Myr was not toxic against IOSE-80 cells for a range of concentrations 0-40μM, it suppressed SKOV3 cell proliferation, migration, and invasion and enhanced apoptosis. Mechanistically, it activated the p38/Sapla signaling pathway, thereby inhibiting oxidative stress and reducing the level of ROS in tumor cells. Our data show that Myr suppresses ovarian cancer cells <i>in vitro</i> and suggests Myr as a candidate agent against ovarian cancer.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-06-01T01:55:15.226Z","creation":"2024-11-21T07:10:19.187Z"},"accession":"S-EPMC9130763","cross_references":{"pubmed":["35646711"],"doi":["10.3389/fonc.2022.903394"]}}