biostudies-literatureUnknown12Li QOvarian cancer is a common malignancy with a mortality and effective, efficient treatments are urgently needed. Myricetin (Myr) is a flavonoid with antioxidant and anticancer properties. Here, we assessed Myr's toxicity on the non-tumor cell line, IOSE-80 and the mechanism by which it suppresses proliferation, migration, and invasion of ovarian cancer SKOV3 cells. The effects of Myr on SKOV3 cells were assessed using CCK-8, oxidative stress, wound healing, Transwell, Hoechst 33258 staining, and western blot assays. Our data show that although Myr was not toxic against IOSE-80 cells for a range of concentrations 0-40μM, it suppressed SKOV3 cell proliferation, migration, and invasion and enhanced apoptosis. Mechanistically, it activated the p38/Sapla signaling pathway, thereby inhibiting oxidative stress and reducing the level of ROS in tumor cells. Our data show that Myr suppresses ovarian cancer cells <i>in vitro</i> and suggests Myr as a candidate agent against ovarian cancer.Frontiers in oncology903394https://www.ebi.ac.uk/biostudies/studies/S-EPMC9130763biostudies-literatureMyricetin Suppresses Ovarian Cancer <i>In Vitro</i> by Activating the p38/Sapla Signaling Pathway and Suppressing Intracellular Oxidative Stress.PMC9130763Ma YLi QGu ZChen STan QfalseMyricetin Suppresses Ovarian Cancer <i>In Vitro</i> by Activating the p38/Sapla Signaling Pathway and Suppressing Intracellular Oxidative Stress.Ovarian cancer is a common malignancy with a mortality and effective, efficient treatments are urgently needed. Myricetin (Myr) is a flavonoid with antioxidant and anticancer properties. Here, we assessed Myr's toxicity on the non-tumor cell line, IOSE-80 and the mechanism by which it suppresses proliferation, migration, and invasion of ovarian cancer SKOV3 cells. The effects of Myr on SKOV3 cells were assessed using CCK-8, oxidative stress, wound healing, Transwell, Hoechst 33258 staining, and western blot assays. Our data show that although Myr was not toxic against IOSE-80 cells for a range of concentrations 0-40μM, it suppressed SKOV3 cell proliferation, migration, and invasion and enhanced apoptosis. Mechanistically, it activated the p38/Sapla signaling pathway, thereby inhibiting oxidative stress and reducing the level of ROS in tumor cells. Our data show that Myr suppresses ovarian cancer cells <i>in vitro</i> and suggests Myr as a candidate agent against ovarian cancer.2022-01-01T00:00:00Z20222025-06-01T01:55:15.226Z2024-11-21T07:10:19.187ZS-EPMC91307633564671110.3389/fonc.2022.903394